Xu Veena Wenqing, Nizami Mohammed Zahedul Islam, Yin Iris Xiaoxue, Niu John Yun, Yu Ollie Yiru, Chu Chun-Hung
Faculty of Dentistry, University of Hong Kong, Hong Kong, China.
Department of Mineralized Tissue Biology and Bioengineering, The Forsyth Institute, Harvard University, Cambridge, MA 02138, USA.
J Funct Biomater. 2023 Dec 23;15(1):10. doi: 10.3390/jfb15010010.
This study comprehensively reviewed the types, properties and potential applications of copper materials for caries management. Two researchers independently searched English publications using PubMed, Scopus and Web of Science. They screened the titles and abstracts of publications presenting original studies for review. They included 34 publications on copper materials, which were categorized as copper and copper alloy materials (13/34, 38%), copper salt materials (13/34, 38%) and copper oxide materials (8/34, 24%). All reported copper materials inhibited the growth of cariogenic bacteria such as and . The materials could be doped into topical agents, restorative fillers, dental adhesives, drinking water, dental implants, orthodontic appliances, mouthwash and sugar. Most publications (29/34, 83%) were laboratory studies, five (5/34, 14%) were animal studies and only one paper (1/34, 3%) was clinical research. In conclusion, copper and copper alloy materials, copper salt materials and copper oxide materials have an antimicrobial property that inhibits cariogenic bacteria and . These copper materials may be incorporated into dental materials and even drinking water and sugar for caries prevention. Most publications are laboratory studies. Further clinical studies are essential to validate the effectiveness of copper materials in caries prevention.
本研究全面综述了用于龋病管理的铜材料的类型、特性及潜在应用。两名研究人员独立使用PubMed、Scopus和Web of Science检索英文出版物。他们筛选了呈现原始研究以供综述的出版物的标题和摘要。他们纳入了34篇关于铜材料的出版物，这些出版物被分类为铜及铜合金材料（13/34，38%）、铜盐材料（13/34，38%）和氧化铜材料（8/34，24%）。所有报道的铜材料均能抑制变形链球菌和远缘链球菌等致龋菌的生长。这些材料可被掺入局部用制剂、修复性填料、牙科粘合剂、饮用水、牙种植体、正畸器械、漱口水和糖类中。大多数出版物（29/34，83%）为实验室研究，5篇（5/34，14%）为动物研究，仅有1篇论文（1/34，3%）为临床研究。总之，铜及铜合金材料、铜盐材料和氧化铜材料具有抑制致龋菌变形链球菌和远缘链球菌的抗菌特性。这些铜材料可被纳入牙科材料甚至饮用水和糖类中以预防龋齿。大多数出版物为实验室研究。进一步的临床研究对于验证铜材料在预防龋齿方面的有效性至关重要。
