Cavas Levent, Kirkiz Ibrahim
The Graduate School of Natural and Applied Sciences, Department of Biotechnology, Dokuz Eylül University, Kaynaklar Campus, 35390, İzmir, Türkiye.
Dokuz Eylül University, Faculty of Science, Department of Chemistry, 35390, Kaynaklar Campus, İzmir, Türkiye.
AMB Express. 2022 Jun 15;12(1):74. doi: 10.1186/s13568-022-01421-x.
Although urinary tract infections (UTIs) affect many people, they are usually a disease observed in women. UTIs happen when exogenous and endogenous bacteria enter the urinary tract and colonize there. Cystitis and pyelonephritis occur when bacteria infect the bladder and the kidneys, respectively. UTIs become much serious if the bacteria causing the infection are antibiotic resistant. Since the pathogenic microorganisms have been adopted to current antibiotics via genetic variations, UTIs have become an even more severe health problem. Therefore, there is a great need for the discovery of novel antibiotics. Genome mining of nonpathogenic and pathogenic Escherichia coli strains for investigating secondary metabolites were conducted by the antiSMASH analysis. When the resulting secondary metabolites were examined, it was found that some of the siderophores are effective in UTIs. In conclusion, since the siderophore production in E. coli is directly related to UTIs, these molecules can be a good target for development of future pharmaceutical approaches and compounds. Siderophores can also be used in industrial studies due to their higher chelating affinity for iron.
尽管尿路感染（UTIs）影响很多人，但它通常是一种在女性中观察到的疾病。当外源和内源细菌进入尿路并在那里定植时，就会发生尿路感染。当细菌分别感染膀胱和肾脏时，会发生膀胱炎和肾盂肾炎。如果引起感染的细菌具有抗生素抗性，尿路感染会变得更加严重。由于致病微生物通过基因变异已适应了当前的抗生素，尿路感染已成为一个更为严重的健康问题。因此，迫切需要发现新型抗生素。通过抗SMASH分析对非致病性和致病性大肠杆菌菌株进行基因组挖掘，以研究次级代谢产物。当检查所得的次级代谢产物时，发现一些铁载体对尿路感染有效。总之，由于大肠杆菌中铁载体的产生与尿路感染直接相关，这些分子可以成为未来药物研发方法和化合物的良好靶点。由于铁载体对铁具有更高的螯合亲和力，它们也可用于工业研究。
