Mouanga Ndzime Yann, Onanga Richard, Kassa Kassa Roland Fabrice, Bignoumba Michelle, Mbehang Nguema Pierre Philippe, Gafou Amahani, Lendamba Roméo Wenceslas, Mbombe Moghoa Kelly, Bisseye Cyrille
Unité de Recherche et d'Analyses Médicales, Laboratoire de Bactériologie, Centre Interdisciplinaire de Recherches Médicales de Franceville, Franceville, BP 769, Gabon.
Laboratoire de Biologie Moléculaire et Cellulaire (LABMC), Université des Sciences et Techniques de Masuku, Franceville, BP 943, Gabon.
Infect Drug Resist. 2021 Feb 16;14:585-594. doi: 10.2147/IDR.S296054. eCollection 2021.
Urinary tract infection is one of the major causes of consultation, microbiologic exploration, intensive use of antibiotics worldwide, and the second leading cause of clinical consultation in community practice. Many bacteria play a role in the urinary tract infections etiology, including such as () and spp.
The study's main objective was to examine the epidemiology of and () uropathogenic strains resistant to antibiotics in Franceville.
The study was carried out between January 2018 and June 2019 in Franceville South-East Gabon. We examined a total of 1086 cytobacteriological urine samples. The identification of and strains was carried out using the Vitek-2 compact automated system and the antibiogram with the disk diffusion method according to the European Committee on Antimicrobial Susceptibility Testing recommendations.
The prevalence of urinary tract infections was 29.2% (317/1086), of which 25.1% and 4.1% were mono-infections and co-infections, respectively. The prevalence of UTIs with was 28.7% (91/317) with a predominance of isolation in women. was responsible for 16.2% (61/317) of UTIs. and Uropathogenic strains showed resistance to beta-lactams, quinolones and cotrimoxazole, whereas Nitrofurantoin, Amikacin, Imipenem and Ertapenem were the most active antibiotics against and uropathogenic strains.
This study showed a high prevalence of urinary tract infections with a major implication of and strains. and presented high frequency of resistance to antibiotics, highlighting the need to adapt their use accordingly at the local level.
尿路感染是全球范围内导致就诊、微生物学检查以及大量使用抗生素的主要原因之一，也是社区医疗中临床就诊的第二大原因。许多细菌在尿路感染的病因中起作用，包括（如） 菌属和 菌属等。
本研究的主要目的是调查法国维尔市对抗生素耐药的 菌属和 （） 尿路致病性菌株的流行病学情况。
该研究于2018年1月至2019年6月在加蓬东南部的法国维尔市开展。我们共检查了1086份尿液细胞细菌学样本。使用Vitek-2 compact自动化系统鉴定 菌属和 菌株，并根据欧洲抗菌药物敏感性试验委员会的建议，采用纸片扩散法进行药敏试验。
尿路感染的患病率为29.2%（317/1086），其中单一感染和混合感染分别占25.1%和4.1%。 菌属引起的尿路感染患病率为28.7%（91/317），女性分离率较高。 菌属导致了16.2%（61/317）的尿路感染。 菌属和 尿路致病性菌株对β-内酰胺类、喹诺酮类和复方新诺明耐药，而呋喃妥因、阿米卡星、亚胺培南和厄他培南是对 菌属和 尿路致病性菌株最有效的抗生素。
本研究表明尿路感染的患病率较高， 菌属和 菌株起主要作用。 菌属和 菌属对抗生素的耐药率较高，凸显了在当地相应调整抗生素使用的必要性。
