Dey P K, Mukhopadhaya N
Indian J Physiol Pharmacol. 1986 Oct-Dec;30(4):300-6.
At there ambient air temperature range, the rectal temperature changes following infusion of histamine either into lateral ventricle (L.V.) or IVth ventricle (IVth V) were studied. At an ambient temperature range of 19-22 degrees C, hypothermia occurred following histamine infusion either into L.V. or IVth V. Hypothermia elicited from infusion of histamine into L.V. was prevented with pretreatment of H1-receptor blocker (mepyramine), but in case of IVth V, it was prevented with H2-receptor blocker(cimetidine). These H1 and H2-receptor antagonists were ineffective in preventing hypothermia following histamine infusion into either L.V. or IVth V, when the ambient air temperature was maintained low (11-13 degrees C).
在该环境空气温度范围内，研究了向侧脑室（L.V.）或第四脑室（IVth V）注入组胺后直肠温度的变化。在19 - 22摄氏度的环境温度范围内，向L.V.或IVth V注入组胺后会出现体温过低。用H1受体阻滞剂（美吡拉敏）预处理可预防因向L.V.注入组胺引起的体温过低，但对于IVth V的情况，用H2受体阻滞剂（西咪替丁）可预防。当环境空气温度保持在低温（11 - 13摄氏度）时，这些H1和H2受体拮抗剂在预防向L.V.或IVth V注入组胺后出现的体温过低方面无效。
