Mukhopadhyay N, Dey P K
Indian J Physiol Pharmacol. 1986 Jan-Mar;30(1):31-42.
Recently histamine is being considered as an important neurotransmitter/neuromodulator in the central nervous system. This has been supported from the present observations with regard to thermoregulatory responses elicited following histamine administration into different CSF compartments. Administration of histamine into the right lateral cerebral ventricle of rats showed a dose dependent fall in rectal temperature. This hypothermic response was evident only at moderately low or at thermoneutral ambient temperature. Administration of histamine into fourth ventricle produced hypothermic response at low ambient temperature and hyperthermia at thermoneutral ambient temperature, which was no longer observed when the ambient temperature remained above the thermoneutral zone. Infusion of histamine into spinal subarachnoid space produced hyperthermia which developed very slowly. However, the infusion of histamine into the subarachnoid space around the brain stem did not exhibit any change in rectal temperature. The significance of these observations has been discussed.
最近，组胺被认为是中枢神经系统中一种重要的神经递质/神经调节剂。这一观点得到了目前的观察结果的支持，这些观察涉及向不同脑脊液腔室注射组胺后引发的体温调节反应。向大鼠右侧侧脑室注射组胺会导致直肠温度呈剂量依赖性下降。这种体温过低反应仅在适度低温或热中性环境温度下明显。向第四脑室注射组胺在低温环境下会产生体温过低反应，在热中性环境温度下会产生体温过高反应，而当环境温度保持在热中性区以上时，这种反应不再出现。向脊髓蛛网膜下腔注入组胺会产生非常缓慢发展的体温过高反应。然而，向脑干周围的蛛网膜下腔注入组胺并未使直肠温度出现任何变化。已对这些观察结果的意义进行了讨论。
