Department of Post Graduate in Health Science, State University of Maringa, Maringa, Parana, Brazil.
Departament of Nursing, State University of Maringa, Maringa, Parana, Brazil.
PLoS One. 2022 Jun 15;17(6):e0269091. doi: 10.1371/journal.pone.0269091. eCollection 2022.
To analyze the characteristics associated with vaccination against Covid-19 in pregnant and postpartum women with Severe Acute Respiratory Syndrome in Brazil and to investigate a possible association between vaccination and the clinical course and outcome of the disease.
Retrospective cohort study of hospitalized pregnant and postpartum women diagnosed with Severe Acute Respiratory Syndrome (SARS) by SARS-CoV-2, presenting onset of signs and symptoms between May and October 2021. Secondary data were used, available in the Influenza Epidemiological Surveillance Information System (SIVEP-Gripe). Data were analyzed using the SPSS statistical program, medians were applied to present continuous variables and frequencies, and proportions were calculated for categorical variables, using logistic and multivariate regression analysis.
The final study population included 3,585 pregnant and postpartum women, of whom 596 (16.6) were vaccinated: 443 (74.3%) received one dose and 153 (25.7%) received two doses. They were factors associated with non-vaccination against Covid-19 age ≤ 19 anos (OR: 2.57; IC95% 1.40;4.71), non-white women (OR: 1.34; IC95% 1.07;1.67) and those who required ventilatory support (OR: 1.51; IC95% 1.19;1.90) and invasive ventilation (OR: 2.05; IC95% 1.37;3.08). On the other hand, vaccination was associated with advanced maternal age (OR: 0.60; IC95% 0.48;0.76), presence of comorbidities (OR: 0.57; IC95% 0.45;0.72) and loss of taste (OR: 0.63; IC95% 0.48;0.82).
Demographic, ethnic-racial and clinical characteristics were associated with the vaccination status of pregnant and postpartum women with SARS by SARS-CoV-2 in Brazil. Vaccination against Covid-19 in the obstetric population has already shown positive results in the evolution of severe cases, which reiterates its importance. It is essential that health services advance vaccination against Covid-19 in the obstetric population, especially adolescentes and non-white women.
分析巴西严重急性呼吸综合征（SARS）孕妇和产后妇女接种 COVID-19 疫苗的特征，并探讨疫苗接种与疾病临床过程和结局之间的可能关联。
这是一项对 2021 年 5 月至 10 月间因 SARS-CoV-2 感染 SARS 而住院的孕妇和产后妇女的回顾性队列研究。使用的是二级数据，来自流感流行病学监测信息系统（SIVEP-Gripe）。使用 SPSS 统计程序进行数据分析，应用中位数表示连续变量，应用频率和比例表示分类变量，使用逻辑和多变量回归分析。
最终研究人群包括 3585 名孕妇和产后妇女，其中 596 人（16.6%）接种了疫苗：443 人（74.3%）接种了一剂，153 人（25.7%）接种了两剂。与未接种 COVID-19 疫苗相关的因素包括年龄≤19 岁（OR：2.57；95%CI 1.40；4.71）、非白人女性（OR：1.34；95%CI 1.07；1.67）和需要通气支持（OR：1.51；95%CI 1.19；1.90）和有创通气（OR：2.05；95%CI 1.37；3.08）。另一方面，疫苗接种与产妇年龄较大（OR：0.60；95%CI 0.48；0.76）、合并症（OR：0.57；95%CI 0.45；0.72）和味觉丧失（OR：0.63；95%CI 0.48；0.82）相关。
巴西严重急性呼吸综合征孕妇和产后妇女的人口统计学、种族和临床特征与 SARS-CoV-2 疫苗接种状况有关。在产科人群中接种 COVID-19 疫苗已经在严重病例的演变中显示出积极的结果，这再次强调了其重要性。卫生服务部门必须在产科人群中推进 COVID-19 疫苗接种，特别是青少年和非白人妇女。
