Department of Veterinary Medicine, Michael Okpara University of Agriculture, Umudike, Nigeria.
Department of Veterinary Pathology, Ahmadu Bello University, Zaria, Nigeria.
J Complement Integr Med. 2022 Jun 15;19(3):705-709. doi: 10.1515/jcim-2020-0451. eCollection 2022 Sep 1.
This study demonstrated the enhancing actions of probiotic on the antitrypanosomal effects of diminazene aceturate in dogs experimentally infected with .
Twenty (20) apparently healthy adult local dogs of both sexes were randomly divided into five groups each containing four dogs. Group I were uninfected and untreated while groups III, IV and V were infected. Groups II, III, IV and V were administered multispecies probiotic (MSP) and/or diminazene aceturate (DA). Parasitaemia was determined, clinical signs recorded and blood collected for haematology.
Results revealed prepatent periods of 4.75 ± 0.25, (4-5) days and significant decrease of parasitaemia, clinical signs and mortality in groups IV and V compared to group III. Mortalities of 100% (group III), 25% (group IV) and 0% (group V) were recorded. Mean packed cells volume, haemoglobin concentration and red blood cells count showed no significant difference in groups I, II, and V, but were significantly decreased in groups III and IV post-treatment.
The administration of MSP to infected dogs enhanced the antitrypanosomal effects of diminazene aceturate.
本研究旨在证明益生菌对感染. 的实验犬中乙酰苯肼的抗锥虫作用具有增强作用。
将 20 只（20 只）明显健康的成年本地雌雄犬随机分为五组，每组 4 只。第 I 组未感染且未治疗，而第 III、IV 和 V 组感染。第 II、III、IV 和 V 组给予多菌种益生菌（MSP）和/或乙酰苯肼（DA）。检测寄生虫血症，记录临床症状并采集血液进行血液学检查。
结果显示，第 IV 和 V 组的无前期期为 4.75±0.25 天（4-5 天），与第 III 组相比，寄生虫血症、临床症状和死亡率显著下降。记录到第 III 组的死亡率为 100%（第 III 组）、25%（第 IV 组）和 0%（第 V 组）。I、II 和 V 组的平均红细胞压积、血红蛋白浓度和红细胞计数无显著差异，但治疗后 III 和 IV 组显著降低。
给感染的狗服用 MSP 增强了乙酰苯肼的抗锥虫作用。
