van Bijsterveld O P, el Batawi Y, Sobhi F S, Nassar M W
Infection. 1987 Jan-Feb;15(1):16-9. doi: 10.1007/BF01646112.
A newly developed 1% eye preparation of the potent antistaphylococcal antibiotic fusidic acid, showed an excellent clinical effect in 206 Egyptian children with external eye infections. The 248 patients included in the study were randomized, in the ratio 5:1, to either fusidic acid or chloramphenicol 0.5% eye drops. Both preparations were given four to six times daily for one week. Bacterial conjunctivitis was diagnosed in 56% of the children. Offending eye pathogens were mainly Staphylococcus aureus (60%), Haemophilus aegyptius (10%), Streptococcus pneumoniae (13%) and Neisseria gonorrhoeae (6%). The overall clinical success rate in children with bacterial conjunctivitis was 85% with fusidic acid, compared to 48% with chloramphenicol (p less than 0.001). The better effect of fusidic acid could be ascribed to a lower frequency of in vitro resistance (16%) in comparison to chloramphenicol (55%). Both drugs were apparently well tolerated and no side-effects were observed.
一种新研发的强效抗葡萄球菌抗生素夫西地酸的1%眼部制剂，在206名患有外眼感染的埃及儿童中显示出了优异的临床效果。该研究纳入的248名患者按5:1的比例随机分为两组，分别使用夫西地酸或0.5%的氯霉素眼药水。两种制剂均每天滴眼四至六次，持续一周。56%的儿童被诊断为细菌性结膜炎。致病眼部病原体主要为金黄色葡萄球菌（60%）、埃及嗜血杆菌（10%）、肺炎链球菌（13%）和淋病奈瑟菌（6%）。细菌性结膜炎患儿使用夫西地酸的总体临床成功率为85%，而使用氯霉素的为48%（p小于0.001）。夫西地酸效果更好可能归因于其体外耐药频率（16%）低于氯霉素（55%）。两种药物的耐受性显然都很好，未观察到副作用。
