Microbiology Department, Institute for Immunology, and Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Microbiology Department, Institute for Immunology, and Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Immunity. 2022 Jun 14;55(6):976-978. doi: 10.1016/j.immuni.2022.05.008.
The microbiome modulates brain function, but the precise routes of gut-brain communication remain unclear. In a recent issue of Science, Gabanyi et al. discover that hypothalamic GABAergic neurons directly recognize microbial muropeptides via NOD2, leading to reduced neuronal activity, loss of appetite, and aberrant thermoregulation.
微生物组调节大脑功能，但肠道-大脑通讯的确切途径仍不清楚。在最近一期的《科学》杂志上，Gabanyi 等人发现，下丘脑 GABA 能神经元通过 NOD2 直接识别微生物肽聚糖，导致神经元活动减少、食欲减退和体温调节异常。
