Taylor A J, Venables K M, Durham S R, Graneek B J, Topping M D
Int Arch Allergy Appl Immunol. 1987;82(3-4):435-9. doi: 10.1159/000234247.
We have studied asthma caused by inhaled acid anhydrides as a model of hapten-induced airway hyperresponsiveness. Inhalation tests with the relevant anhydride in sensitised individuals reproducibly provoked a significant increase in non-specific airway responsiveness identifiable 3 h after the test and prior to the development of the late asthmatic reaction. Seven cases of asthma caused by tetrachlorophthalic anhydride (TCPA) had specific IgE in their serum to a TCPA-human serum albumin conjugate. RAST inhibition studies showed the anhydride to be involved in the antibody-combining site. Survey of the factory population where these 7 cases worked allowed investigation of the determinants of the specific IgE response: its presence was associated with intensity of exposure and current cigarette smoking; in addition smoking interacted with atopy to increase the prevalence of specific IgE. During a 5-year period of avoidance of exposure to TCPA specific IgE declined exponentially with a half-life of one year, suggesting continuing IgE secretion. Five years after avoidance of exposure, airway hyperresponsiveness remained increased in several cases.
我们已将吸入酸酐所致哮喘作为半抗原诱导气道高反应性的模型进行研究。在致敏个体中用相关酸酐进行吸入试验，可重复性地引发非特异性气道反应性显著增加，在试验后3小时且在迟发性哮喘反应出现之前即可识别。7例由四氯邻苯二甲酸酐（TCPA）引起的哮喘患者血清中存在针对TCPA - 人血清白蛋白偶联物的特异性IgE。放射性变应原吸附试验（RAST）抑制研究表明酸酐参与了抗体结合位点。对这7例患者工作的工厂人群进行调查，有助于研究特异性IgE反应的决定因素：其存在与接触强度和当前吸烟情况相关；此外，吸烟与特应性相互作用会增加特异性IgE的患病率。在避免接触TCPA的5年期间，特异性IgE呈指数下降，半衰期为1年，提示IgE持续分泌。避免接触5年后，数例患者的气道高反应性仍持续升高。
