Söderström T, Söderström R, Avanzini A, Brandtzaeg P, Karlsson G, Hanson L A
Int Arch Allergy Appl Immunol. 1987;82(3-4):476-80. doi: 10.1159/000234258.
Low levels of single or multiple serum immunoglobulin G (IgG) subclasses is a common finding among patients with increased susceptibility to infections. In this investigation we summarize data from studies of 503 subclass-deficient individuals. Low IgG2 levels was the most common deficiency among children, and boys were more often deficient than girls. From the age of 16, females dominated, and the most frequent finding was low IgG3 levels. In vitro T or B lymphocyte dysfunction was demonstrated in 75% of the individuals, suggesting that low subclass levels may be indicators of an underlying defect at the B cell or possibly T cell level. Vaccinations and mucosal biopsies were performed to evaluate which patients may be helped by immunoglobulin substitution therapy.
血清中单一或多种免疫球蛋白G（IgG）亚类水平低下是易感染患者中的常见表现。在本研究中，我们总结了对503名亚类缺陷个体的研究数据。低IgG2水平是儿童中最常见的缺陷，男孩比女孩更易出现缺陷。16岁起，女性占主导，最常见的表现是低IgG3水平。75%的个体存在体外T或B淋巴细胞功能障碍，提示低亚类水平可能是B细胞或可能是T细胞水平潜在缺陷的指标。进行了疫苗接种和黏膜活检，以评估哪些患者可能从免疫球蛋白替代疗法中获益。
