Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Japan.
Intern Med. 2023 Jan 1;62(1):123-127. doi: 10.2169/internalmedicine.9485-22. Epub 2022 Jun 14.
We herein report a 20-year-old woman who developed eosinophilic granulomatosis with polyangiitis (EGPA) and portal vein thrombosis (PVT). EGPA was diagnosed based on the patient's history of asthma, hypereosinophilia, and mononeuritis complex. Thrombocytopenia and liver dysfunction were observed, necessitating contrast-enhanced computed tomography (CECT), which revealed PVT. Her symptoms soon improved with glucocorticoids and anticoagulation therapy. As patients with EGPA often suffer from asthma, they can be hesitant to undergo CECT. However, if patients with EGPA show uncertain thrombocytopenia with liver dysfunction, a further evaluation using CECT is warranted to detect PVT.
我们在此报告一例 20 岁女性，其发生嗜酸性肉芽肿伴多血管炎（EGPA）和门静脉血栓形成（PVT）。基于患者的哮喘、嗜酸性粒细胞增多和单神经病的病史，诊断为 EGPA。观察到血小板减少和肝功能障碍，需要进行增强计算机断层扫描（CECT），结果显示 PVT。她的症状很快通过糖皮质激素和抗凝治疗得到改善。由于 EGPA 患者常有哮喘，他们可能会犹豫是否进行 CECT。然而，如果 EGPA 患者出现不确定的血小板减少症伴肝功能障碍，建议进一步使用 CECT 评估以检测 PVT。
