Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
Quantitative Imaging Lab Bonn (QILaB), University Hospital Bonn, Bonn, Germany.
Sci Rep. 2022 Jun 15;12(1):9934. doi: 10.1038/s41598-022-13404-w.
To explore the image quality and radiation dose of dual source high-pitch cardiac computed tomography with tailored contrast injection protocols for pediatric congenital heart disease patients (CHD). In total, 27 infants with CHD (median age 109 days [IQR 6-199]) were retrospectively analyzed regarding dose length product (DLP) and effective dose (ED) after undergoing cardiothoracic CT imaging. Scan parameters were adjusted on a dual source/detector CT (DSCT) to minimize radiation dose while maintaining adequate quality. Image acquisition was performed at 70% of the R-R interval. Dose reducing measures included prospective electrocardiogram gating, utilizing slow injection velocities and foregoing bolus tracking during contrast injection. Image quality was assessed for artefacts, vessel definition, and noise on a 5-point scale (1 non-diagnostic, 5 excellent). Series were scored on a 0-to-3-point scale regarding answered clinical questions (0 non-diagnostic, 3 all clinical questions could be answered). The median DLP was 5.2 mGy*cm (IQR 3.5-7.8) leading to a median ED of 0.20 mSv (IQR 0.14-0.30). On average the acquired images scored 13.3 ± 2.1 (SD) out of a maximum 15 points with an intraclass correlation coefficient (ICC) of 0.94. All acquired series were able to fully answer all clinical questions scoring maximum points (ICC 1.0). Dual source high pitch CT protocols combined with custom contrast agent injection protocols in pediatric patients with CHD delivered sufficiently high diagnostic imaging quality combined with low submilisievert radiation doses. Prospective high pitch imaging is a reliable method for depiction of cardiac anatomy even in very young pediatric CHD patients with elevated heart rates.
探讨针对小儿先天性心脏病(CHD)患者量身定制对比剂注射方案的双源高速心脏 CT 的图像质量和辐射剂量。共回顾性分析了 27 例 CHD 婴儿(中位年龄 109 天[IQR 6-199])的剂量长度乘积(DLP)和有效剂量(ED),这些婴儿均接受了心胸 CT 成像。在双源/探测器 CT(DSCT)上调整扫描参数,在保持足够质量的同时尽量降低辐射剂量。在 70%的 R-R 间期进行图像采集。降低剂量的措施包括前瞻性心电图门控、使用较慢的注射速度和在对比剂注射期间不使用团注追踪。使用 5 分制评估图像质量的伪影、血管清晰度和噪声(1 分为不可诊断,5 分为极好)。根据回答临床问题的情况对系列进行 0 至 3 分评分(0 分为不可诊断,3 分为所有临床问题均可回答)。中位 DLP 为 5.2 mGy*cm(IQR 3.5-7.8),中位 ED 为 0.20 mSv(IQR 0.14-0.30)。平均而言,获得的图像得分为 13.3±2.1(SD),满分 15 分,组内相关系数(ICC)为 0.94。所有采集的系列都能够通过获得满分(ICC 1.0)来完全回答所有临床问题。在 CHD 患儿中,结合定制对比剂注射方案的双源高速 CT 方案可提供足够高的诊断成像质量,同时辐射剂量低至毫希沃特以下。前瞻性高速成像即使在心率较高的非常年幼的 CHD 患儿中也是一种可靠的心脏解剖显示方法。