Theorell T, Hamsten A, de Faire U, Orth-Gomér K, Perski A
Int J Cardiol. 1987 Apr;15(1):33-46. doi: 10.1016/0167-5273(87)90290-7.
All male patients in the greater Stockholm area who had survived a myocardial infarction below the age of 45 were examined with regard to medical and psychosocial risk factors 3-6 months after the onset of the infarction. For each patient, a male control subject was randomly selected after matching with regard to age and residence area. In the patient group, coronary angiograms were performed and rated with regard to degree of coronary atherosclerosis. The psychosocial variables were not correlated with degree of coronary atherosclerosis. Excessive work demands combined with boredom at work ("variety" and "intellectual discretion") were significantly more often reported by the patients after adjustment had been made for life style factors. In the multivariate analysis a high LDL/HDL cholesterol ratio, a high cumulative tobacco consumption, high demands in relation to variety at work as well as high demands in relation to influence over work and finally a low alcohol consumption were significant independent predictors of case status. Excessive work demands in themselves did not differentiate cases from controls.
对斯德哥尔摩大区所有45岁以下心肌梗死存活的男性患者，在心肌梗死发病后3至6个月检查其医学和社会心理风险因素。为每位患者，在年龄和居住地区匹配后随机选择一名男性对照对象。在患者组中，进行冠状动脉造影并根据冠状动脉粥样硬化程度进行评分。社会心理变量与冠状动脉粥样硬化程度无关。在对生活方式因素进行调整后，患者报告工作需求过高且工作乏味（“多样性”和“智力自主性”）的情况明显更为常见。在多变量分析中，高LDL/HDL胆固醇比值、高累积烟草消费量、对工作多样性的高要求以及对工作影响力的高要求，最后还有低酒精消费量是病例状态的显著独立预测因素。工作需求过高本身并不能区分病例和对照。
