Abrishami Mojtaba, Hosseini Seyedeh Maryam, Shoeibi Nasser, Heidarzadeh Hamid Reza
Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Case Rep Ophthalmol Med. 2022 Jun 6;2022:1237148. doi: 10.1155/2022/1237148. eCollection 2022.
To report a case of protein C deficiency with paracentral acute middle maculopathy (PAMM) and nonischemic central retinal vein obstruction (NI-CRVO). . A previously healthy twenty-one-year-old male was referred with sudden-onset, painless, unilateral paracentral scotomata in the right eye for a week. His uncorrected visual acuity was 20/20 in both eyes. In fundus examination of the right eye, mild venous tortuosity, retinal hemorrhages, and a gray-white opacity in the papillomacular bundle were observed. In the macular spectral-domain optical coherence tomography images, a hyperreflective band was noticed at the level of the inner nuclear layer, indicating PAMM. Fundus appearance and fluorescein angiography findings indicated NI-CRVO diagnosis made. The systemic and laboratory evaluations disclosed a protein C deficiency.
In this report, in a healthy young male, combined PAMM and NI-CRVO showed to be the cause of blurred vision in the setting of protein C deficiency.
报告一例伴有黄斑中心凹旁急性黄斑病变（PAMM）和非缺血性视网膜中央静脉阻塞（NI-CRVO）的蛋白C缺乏症病例。一名此前健康的21岁男性因右眼突发、无痛性、单侧黄斑中心凹旁暗点一周前来就诊。他双眼的裸眼视力均为20/20。在右眼眼底检查中，观察到轻度静脉迂曲、视网膜出血以及乳头黄斑束处的灰白色混浊。在黄斑区光谱域光学相干断层扫描图像中，在内核层水平发现一条高反射带，提示为PAMM。眼底外观和荧光素血管造影结果表明诊断为NI-CRVO。全身和实验室评估发现存在蛋白C缺乏症。
在本报告中，一名健康年轻男性中，PAMM和NI-CRVO合并出现是蛋白C缺乏情况下视力模糊的原因。
