Bailey Sarah Lou, Buckingham Christian, Maxwell-Scott Hector, Rashidghamat Ellie, Ferguson Felicity J, Malhomme de la Roche Helena, Goldenberg Simon D
Directorate of Infection, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
Centre for Clinical Infection and Diagnostics Research, Department of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom.
Skin Appendage Disord. 2022 May;8(3):211-220. doi: 10.1159/000522404. Epub 2022 Mar 17.
Hidradenitis suppurativa (HS) is a chronic inflammatory disease characterized by recurrent nodules, abscesses, and sinus tracts, resulting in scarring. Patients suffer significantly impacted quality of life (QoL), manifested by anxiety and depression. We describe microbial isolates identified from active sites in adults with HS, and explore associations between organisms isolated, disease severity, and QoL.
Observational study over 2 years. Assessment was made of disease severity using the Hurley staging score and of QoL scores, and subjective assessment. Wound swab samples were obtained from sites of active disease. Descriptive summary statistics and tests of significance were used to analyse the data.
Two hundred and twelve patients participated, resulting in 352 episodes, and 501 lesion swab samples. 54% were female and 59% were obese, median age of 37 years. A lower proportion of Gram-negative organisms and more staphylococcal and streptococcal organisms were isolated from sites of disease in individuals with stage 3 disease compared to those with stage 1-2 disease ( = 0.001). We found no association between microbial isolation and QoL.
DISCUSSION/CONCLUSIONS: Hurley stage 3 disease is associated with more infected lesions than Hurley stage 1-2 disease, but the QoL experienced by patients with HS is determined by factors other than infection.
化脓性汗腺炎（HS）是一种慢性炎症性疾病，其特征为反复发作的结节、脓肿和窦道，并导致瘢痕形成。患者的生活质量（QoL）受到严重影响，表现为焦虑和抑郁。我们描述了从成年HS患者的活动部位分离出的微生物，并探讨了分离出的微生物、疾病严重程度和生活质量之间的关联。
为期2年的观察性研究。使用赫尔利分期评分评估疾病严重程度，使用生活质量评分和主观评估。从活动性疾病部位采集伤口拭子样本。使用描述性汇总统计和显著性检验分析数据。
212名患者参与，共产生352个发病阶段，以及501份病变拭子样本。54%为女性，59%为肥胖者，中位年龄为37岁。与1-2期疾病患者相比，3期疾病患者疾病部位分离出的革兰氏阴性菌比例较低，葡萄球菌和链球菌比例较高（P = 0.001）。我们发现微生物分离与生活质量之间无关联。
讨论/结论：与赫尔利1-2期疾病相比，赫尔利3期疾病的感染性病变更多，但HS患者的生活质量是由感染以外的因素决定的。
