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在混合效应模型中,将样本量视为截断泊松随机变量。

Considering the sample sizes as truncated Poisson random variables in mixed effects models.

作者信息

Nunes Célia, Moreira Elsa, Ferreira Sandra S, Ferreira Dário, Mexia João T

机构信息

Department of Mathematics and Center of Mathematics and Applications, University of Beira Interior, Covilhã, Portugal.

CMA - Center of Mathematics and its Applications, Faculty of Science and Technology, New University of Lisbon, Lisbon, Portugal.

出版信息

J Appl Stat. 2019 Jul 14;47(13-15):2641-2657. doi: 10.1080/02664763.2019.1641188. eCollection 2020.

Abstract

When applying analysis of variance, the sample sizes may not be previously known, so it is more appropriate to consider them as realizations of random variables. A motivating example is the collection of observations during a fixed time span in a study comparing, for example, several pathologies of patients arriving at a hospital. This paper extends the theory of analysis of variance to those situations considering mixed effects models. We will assume that the occurrences of observations correspond to a counting process and the sample dimensions have Poisson distribution. The proposed approach is applied to a study of cancer patients.

摘要

在应用方差分析时,样本量可能事先并不知晓,因此将它们视为随机变量的实现会更为合适。一个具有启发性的例子是,在一项研究中,比如比较前往某医院就诊的患者的几种病症,在固定时间段内收集观测数据。本文将方差分析理论扩展到考虑混合效应模型的那些情形。我们将假定观测值的出现对应一个计数过程,并且样本维度具有泊松分布。所提出的方法应用于一项癌症患者研究。

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