Sakai Naomi S, Bhagwanani Anisha, Bray Timothy Jp, Hall-Craggs Margaret A, Taylor Stuart Andrew
University College London Hospital, London, UK.
BJR Open. 2021 Nov 26;3(1):20210048. doi: 10.1259/bjro.20210048. eCollection 2021.
To assess body composition in patients with non-small cell lung cancer (NSCLC) and colorectal cancer using whole-body MRI and relate this to clinical outcomes.
53 patients with NSCLC (28 males, 25 females; mean age 66.9) and 74 patients with colorectal cancer (42 males, 32 females; mean age 62.9) underwent staging whole-body MRI scans, which were post-processed to derive fat mass (FM), fat free mass (FFM) and skeletal muscle (SM) indices and SM fat fraction (FF). These were compared between the two cancer cohorts using two-sided -tests and the chi-squared test. Measurements of body composition were correlated with outcomes including length of hospital stay, metastatic status and mortality.
Patients with NSCLC had significantly lower FFM ( = 0.0071) and SM ( = 0.0084) indices. Mean SM FF was greater in patients with NSCLC ( = 0.0124) and was associated with longer hospital stay (). There was no significant relationship between FM, FFM and SM indices and length of hospital stay, metastatic status or mortality.
Patients with NSCLC had lower FFM and SM indices than patients with colorectal cancer and greater SMFF, indicating lower SM mass with fatty infiltration. These findings reflect differences in the phenotype of the two groups and suggest patients with lung cancer are more likely to require additional nutritional support.
Body composition differs between NSCLC and colorectal cancer. Patients with NSCLC have both a reduced SM mass and greater SM FF suggesting that they are more nutritionally deplete than patients with colorectal cancer.
使用全身磁共振成像（MRI）评估非小细胞肺癌（NSCLC）和结直肠癌患者的身体成分，并将其与临床结局相关联。
53例NSCLC患者（28例男性，25例女性；平均年龄66.9岁）和74例结直肠癌患者（42例男性，32例女性；平均年龄62.9岁）接受了分期全身MRI扫描，对扫描结果进行后处理以得出脂肪量（FM）、去脂体重（FFM）、骨骼肌（SM）指数和SM脂肪分数（FF）。使用双侧t检验和卡方检验对这两个癌症队列之间的上述指标进行比较。身体成分测量结果与包括住院时间、转移状态和死亡率在内的结局相关联。
NSCLC患者的FFM指数（P = 0.0071）和SM指数（P = 0.0084）显著更低。NSCLC患者的平均SM FF更高（P = 0.0124），且与更长的住院时间相关（P<0.05）。FM、FFM和SM指数与住院时间、转移状态或死亡率之间无显著关系。
NSCLC患者的FFM和SM指数低于结直肠癌患者，且SMFF更高，表明SM质量更低且存在脂肪浸润。这些发现反映了两组患者表型的差异，提示肺癌患者更可能需要额外的营养支持。
NSCLC和结直肠癌患者的身体成分存在差异。NSCLC患者的SM质量降低且SM FF更高，表明他们比结直肠癌患者的营养消耗更大。
