研究了形态正常的猫脑的区域性表观扩散系数值。
Investigated regional apparent diffusion coefficient values of the morphologically normal feline brain.
机构信息
Clinic for Diagnostic Imaging, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
出版信息
J Feline Med Surg. 2022 Aug;24(8):e214-e222. doi: 10.1177/1098612X221101535. Epub 2022 Jun 16.
OBJECTIVES
Diffusion-weighted imaging (DWI) MRI is increasingly available in veterinary medicine for investigation of the brain. However, apparent diffusion coefficient (ADC) values have only been reported in a small number of cats or in research settings. The aim of this study was to investigate the ADC values of different anatomical regions of the morphologically normal brain in a feline patient population. Additionally, we aimed to assess the possible influence on the ADC values of different patient-related factors, such as sex, body weight, age, imaging of the left and right side of the cerebral hemispheres and white vs grey matter regions.
METHODS
This retrospective study included cats undergoing an MRI (3T) examination with DWI sequences of the head at the Vetsuisse Faculty of the University Zurich between 2015 and 2021. Only cats with morphologically normal brains were included. On the ADC maps, 10 regions of interest (ROIs) were manually drawn on the following anatomical regions: caudate nucleus; internal capsule (two locations); piriform lobe; thalamus; hippocampus; cortex cerebri (two locations); cerebellar hemisphere; and one ROI in the centre of the cerebellar vermis. Except for the ROI at the cerebellar vermis, each ROI was drawn in the left and right hemisphere. The ADC values were calculated by the software and recorded.
RESULTS
A total of 129 cats were included in this study. The ADC varied in the different ROIs, with the highest mean ADC value in the hippocampus and the lowest in the cerebellar hemisphere. ADC was significantly lower in the white cerebral matter compared with the grey matter. ADC values were not influenced by age, with the exception of the hippocampus and the cingulate gyrus.
CONCLUSION AND RELEVANCE
ADC values of different anatomical regions of the morphologically normal feline brain in a patient population of 129 cats in a clinical setting are reported for the first time.
目的
扩散加权成像（DWI）MRI 在兽医领域越来越多地用于脑部研究。然而，表观扩散系数（ADC）值仅在少数猫或研究环境中报告过。本研究旨在调查形态正常的猫脑不同解剖区域的 ADC 值。此外，我们还旨在评估不同与患者相关的因素（如性别、体重、年龄、大脑左右半球成像以及白质与灰质区域）对 ADC 值的可能影响。
方法
本回顾性研究纳入了 2015 年至 2021 年期间在苏黎世大学兽医学院接受头部 MRI（3T）检查并带有 DWI 序列的猫。仅纳入形态正常的猫。在 ADC 图谱上，手动在以下解剖区域的 10 个感兴趣区域（ROI）上绘制 ROI：尾状核；内囊（两个位置）；梨状叶；丘脑；海马体；大脑皮层（两个位置）；小脑半球；小脑蚓部的一个 ROI。除了小脑蚓部的 ROI 外，每个 ROI 都在左、右半球绘制。软件计算并记录 ADC 值。
结果
本研究共纳入 129 只猫。不同 ROI 之间的 ADC 值存在差异，其中海马体的平均 ADC 值最高，小脑半球的 ADC 值最低。与灰质相比，白质的 ADC 值显著降低。除了海马体和扣带回外，ADC 值不受年龄影响。
结论和相关性
首次报道了临床环境中 129 只猫形态正常的猫脑不同解剖区域的 ADC 值。
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