Andrology Laboratory, West China Hospital, Sichuan University, Chengdu 610041, China.
Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.
Asian J Androl. 2023 Mar-Apr;25(2):271-276. doi: 10.4103/aja202237.
Literature regarding the impacts of heavy metal exposure on erectile dysfunction (ED) is scarce. We aimed to evaluate the correlation between 10 urinary metals and ED in a large, nationally representative adult male sample. The dataset was extracted from the National Health and Nutrition Examination Survey (NHANES) during the period of 2001-2002 and 2003-2004. Weighted proportions and multivariable logistic regression analysis adjusted for confounding variables were utilized to determine the relationship between metal exposure and ED. Weighted quantile sum (WQS) regression was utilized to evaluate the impact of a mixture of urinary metals on ED. A total of 1328 participants were included in our study. In multivariable logistic regression analysis, cobalt (Co) and antimony (Sb) were positively associated with ED (odds ratio [OR]: 1.36, 95% confidence interval [CI]: 1.10-1.73, P = 0.020; and OR: 1.41, 95% CI: 1.12-1.77, P = 0.018, respectively) after full adjustment. Men in tertile 4 for Co (OR: 1.49, 95% CI: 1.02-2.41, P for trend = 0.012) and Sb (OR: 1.53, 95% CI: 1.08-2.40, P for trend = 0.041) had significantly higher odds of ED than those in tertile 1. Furthermore, the WQS index was significantly linked with increased odds of ED after full adjustment (OR: 1.31, 95% CI: 1.04-1.72, P < 0.05). Our study expanded on previous literature indicating the possible role of heavy metal exposure in the etiology of ED. The evaluation of heavy metal exposure should be included in the risk assessment of ED.
有关重金属暴露对勃起功能障碍（ED）影响的文献很少。我们旨在评估大量具有全国代表性的成年男性样本中 10 种尿金属与 ED 之间的相关性。该数据集取自 2001-2002 年和 2003-2004 年期间的国家健康和营养检查调查（NHANES）。利用加权比例和多变量逻辑回归分析调整混杂变量，以确定金属暴露与 ED 之间的关系。利用加权分位数总和（WQS）回归评估尿金属混合物对 ED 的影响。我们的研究共纳入了 1328 名参与者。在多变量逻辑回归分析中，钴（Co）和锑（Sb）与 ED 呈正相关（比值比[OR]：1.36，95%置信区间[CI]：1.10-1.73，P = 0.020；和 OR：1.41，95% CI：1.12-1.77，P = 0.018，分别）在充分调整后。Co 四分位 4 组（OR：1.49，95% CI：1.02-2.41，P 趋势 = 0.012）和 Sb 四分位 4 组（OR：1.53，95% CI：1.08-2.40，P 趋势 = 0.041）的男性 ED 发病几率明显高于四分位 1 组。此外，在充分调整后，WQS 指数与 ED 发病几率的增加显著相关（OR：1.31，95% CI：1.04-1.72，P <0.05）。我们的研究扩展了先前的文献，表明重金属暴露可能在 ED 的病因学中起作用。应将重金属暴露评估纳入 ED 的风险评估中。
