一种用于细菌诱导炎症的近红外二区成像及伤口细菌感染治疗的AgS@ZIF-Van纳米系统。
An AgS@ZIF-Van nanosystem for NIR-II imaging of bacterial-induced inflammation and treatment of wound bacterial infection.
作者信息
Huang Yao, Geng Hongchao, Wu Zeming, Sun Leilei, Ji Chenhui, Grimes Craig A, Feng Xinxin, Cai Qingyun
机构信息
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, Hunan, China.
Inner Mongolia Environmental Monitoring Center, Hohhot 010011, Inner Mongolia, China.
出版信息
Biomater Sci. 2022 Jul 12;10(14):3972-3980. doi: 10.1039/d2bm00550f.
Bacterial diseases pose a serious threat to human health. Continued development of precise diagnostic methods and synergistic therapy techniques for combating bacteria are needed. Herein a hybrid nanosystem (AgS@ZIF-Van NS) was constructed by one-step self-assembly of Zn, vancomycin (Van) and AgS quantum dots (QDs). The nanosystem possesses excellent second near-infrared transparency window (NIR-II) fluorescence properties (∼1200 nm emission wavelength), good photothermal conversion properties, and biocompatibility. The material system enables precise, targeted NIR-II fluorescent imaging of bacterial inflammation as well as promoting anti-bacterial and wound healing effects.
细菌疾病对人类健康构成严重威胁。需要持续开发用于对抗细菌的精确诊断方法和协同治疗技术。在此，通过锌、万古霉素（Van）和硫化银量子点（QDs）的一步自组装构建了一种混合纳米系统（AgS@ZIF-Van NS）。该纳米系统具有出色的第二近红外透明窗口（NIR-II）荧光特性（发射波长约为1200 nm）、良好的光热转换特性和生物相容性。该材料系统能够对细菌炎症进行精确的靶向NIR-II荧光成像，并具有促进抗菌和伤口愈合的作用。
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