IEEE Trans Med Imaging. 2022 Nov;41(11):3301-3308. doi: 10.1109/TMI.2022.3183948. Epub 2022 Oct 27.
Vascular interventions are a promising application of Magnetic Particle Imaging enabling a high spatial and temporal resolution without using ionizing radiation. The possibility to visualize the vessels as well as the devices, especially at the same time using multi-contrast approaches, enables a higher accuracy for diagnosis and treatment of vascular diseases. Different techniques to make devices MPI visible have been introduced so far, such as varnish markings or filling of balloons. However, all approaches include challenges for in vivo applications, such as the stability of the varnishing or the visibility of tracer filled balloons in deflated state. In this contribution, we present for the first time a balloon catheter that is molded from a granulate incorporating nanoparticles and can be visualized sufficiently in MPI. Computed tomography is used to show the homogeneous distribution of particles within the material. Safety measurements confirm that the incorporation of nanoparticles has no negative effect on the balloon. A dynamic experiment is performed to show that the inflation as well as deflation of the balloon can be imaged with MPI.
血管介入是磁共振粒子成像的一个很有前景的应用，它可以在不使用电离辐射的情况下实现高空间和时间分辨率。能够可视化血管和器械的可能性，特别是同时使用多对比度方法，可以提高血管疾病的诊断和治疗的准确性。迄今为止，已经引入了不同的技术来使器械在 MPI 中可见，例如清漆标记或球囊填充。然而，所有方法都为体内应用带来了挑战，例如清漆的稳定性或在瘪气球状态下示踪剂填充球囊的可见性。在本研究中，我们首次提出了一种由包含纳米粒子的颗粒模制而成的球囊导管，并且可以在 MPI 中充分可视化。计算机断层扫描用于显示材料内颗粒的均匀分布。安全测量证实，纳米粒子的掺入对气球没有负面影响。进行了一项动态实验，以证明可以使用 MPI 对气球的充气和放气进行成像。
