Department of Urology, Hanyang University College of Medicine, Seoul, Korea.
Department of Medical and Digital Engineering, Hanyang University, Seoul, Korea.
PLoS One. 2022 Jun 16;17(6):e0269894. doi: 10.1371/journal.pone.0269894. eCollection 2022.
Male infertility affects up to 12% of men. Although manual testing using microscope examination and computer-assisted semen analysis are standard methods of measuring sperm count and motility, these methods are limited by being laboratory based. To investigate the usefulness of a novel semen analysis device using a smartphone camera. This prospective multicenter randomized parallel design trial enrolled 200 men aged ≥19 years of age between August and December 2018. Each subject was advised to use the Smart Sperm Test for OVIEW-M at home after 5 days of abstinence. The accuracy of the OVIEW-M test relative to the in-hospital test was determined. A questionnaire was administered to assess subject likelihood of using the OVIEW-M. Measurements using standard methods and the OVIEW-M showed similar sperm counts and similar motile sperm counts. Correlation analysis showed significant correlations between sperm count and sperm motility when measured by OVIEW-M tests (r = 0.893, p < 0.01) and standard microscope examination (r = 0.883, p < 0.01). Of the subjects who responded to questionnaires, 43% regarded the results of the OVIEW-M tests as reliable and 18% as unreliable. Semen analysis with the smartphone-based application and accessories yielded results not inferior to those of laboratory tests. Men who visit the hospital for evaluation of infertility can easily perform OVIEW-M semen tests at home.
男性不育症影响了多达 12%的男性。虽然使用显微镜检查和计算机辅助精液分析的手动测试是测量精子计数和活力的标准方法，但这些方法受到实验室的限制。为了研究一种使用智能手机摄像头的新型精液分析设备的有用性。这项前瞻性多中心随机平行设计试验招募了 200 名年龄在 19 岁及以上的男性，他们于 2018 年 8 月至 12 月间参加。每位受试者均被建议在禁欲 5 天后在家中使用 Smart Sperm Test for OVIEW-M。确定 OVIEW-M 测试相对于院内测试的准确性。问卷调查评估受试者使用 OVIEW-M 的可能性。使用标准方法和 OVIEW-M 进行的测量显示，精子计数和活动精子计数相似。相关分析显示，O VIEW-M 测试（r = 0.893，p <0.01）和标准显微镜检查（r = 0.883，p <0.01）测量时精子计数和精子活力之间存在显著相关性。对回答问卷的受试者进行分析，43%的人认为 OVIEW-M 测试结果可靠，18%的人认为不可靠。基于智能手机的应用程序和附件的精液分析产生的结果不劣于实验室测试的结果。因评估不育症而到医院就诊的男性可以在家中轻松进行 OVIEW-M 精液测试。
