Allen T A, Jaenke R S, Fettman M J
J Am Vet Med Assoc. 1987 Apr 1;190(7):866-8.
A simple method for estimating the rate of progression of chronic renal failure was evaluated in 11 dogs. The plot of the reciprocal of the serum creatinine concentration vs age declined linearly, and projection of the regression line to the abscissa accurately predicted each dog's age at the time of death attributable to renal failure. The linear decline of the reciprocal of the serum creatinine concentration vs age indicated that nephrons may be lost at a constant rate in dogs with chronic renal failure. Changes in the slope of this line may provide a means of evaluating response to treatment.
在11只犬中评估了一种估计慢性肾衰竭进展速率的简单方法。血清肌酐浓度倒数与年龄的关系图呈线性下降，将回归线投影到横坐标可准确预测每只犬因肾衰竭死亡时的年龄。血清肌酐浓度倒数与年龄的线性下降表明，慢性肾衰竭犬的肾单位可能以恒定速率丢失。这条线斜率的变化可能提供一种评估治疗反应的方法。
