WF-3405，一种新型抗肿瘤抗生素。分类学、分离、结构解析及生物学特性

WF-3405, a novel antitumor antibiotic. Taxonomy, isolation, structure elucidation and biological properties.

作者信息

Kiyoto S, Murai H, Tsurumi Y, Terano H, Kohsaka M, Takase S, Uchida I, Hashimoto M, Aoki H, Imanaka H

出版信息

J Antibiot (Tokyo). 1987 Mar;40(3):290-5. doi: 10.7164/antibiotics.40.290.

DOI:10.7164/antibiotics.40.290

Abstract

A new antitumor antibiotic, WF-3405 was isolated from the culture of Amauroascus aureus F-3405. The structure has been determined as 1,5-dioxiranyl-1,2,3,4,5-pentanepentanol on the basis of spectroscopic and chemical evidence. WF-3405 exhibits strong inhibitory activity against various murine tumors including leukemia P388, leukemia L1210 and Lewis lung carcinoma.

摘要

一种新的抗肿瘤抗生素WF - 3405是从金黄色暗孢霉F - 3405的培养物中分离得到的。基于光谱和化学证据，其结构已确定为1,5 - 二环氧乙烷 - 1,2,3,4,5 - 戊烷戊醇。WF - 3405对多种小鼠肿瘤表现出强烈的抑制活性，包括白血病P388、白血病L1210和刘易斯肺癌。