Rask-Andersen H, Erwall C, Steel K P, Friberg U
Hear Res. 1987;26(2):177-90. doi: 10.1016/0378-5955(87)90110-9.
The response of the endolymphatic sac to a disturbance in endolymph homeostasis was investigated by examining the sac in a mouse mutant, viable dominant spotting, which is known to exhibit primary strial dysfunction and cochleo-saccular degeneration. The function of the vascular stria was assessed by measuring the endocochlear potential and the sacs were then studied by light and transmission electron microscopy. The endolymphatic sac was found to be morphologically abnormal in these mutants, the main abnormality being the presence of granular epithelial cells, which showed clear histological signs of secretory activity. A stainable precipitate, believed to be secreted by the granular cells, was observed in the lumen of the endolymphatic sac in the mutants. The findings strengthen the view that the sac is involved in the regulation of endolymph volume and pressure.
通过研究一种小鼠突变体——可行显性斑点（viable dominant spotting）中的内淋巴囊，来探究内淋巴囊对内淋巴稳态紊乱的反应。已知该突变体表现出原发性螺旋韧带功能障碍和耳蜗球囊变性。通过测量耳蜗内电位来评估血管纹的功能，然后用光镜和透射电子显微镜对内淋巴囊进行研究。发现这些突变体的内淋巴囊在形态上异常，主要异常是存在颗粒状上皮细胞，这些细胞显示出明显的分泌活动组织学迹象。在突变体的内淋巴囊腔中观察到一种可染色沉淀物，据信是由颗粒细胞分泌的。这些发现强化了内淋巴囊参与内淋巴液体积和压力调节的观点。
