Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, NO. 95 Yong-An Road, Xi-Cheng District, Beijing, 100050, People's Republic of China.
BMC Anesthesiol. 2022 Jun 16;22(1):183. doi: 10.1186/s12871-022-01725-2.
Available literature indicates that long-term drinkers demand a higher dose of propofol for induction of anesthesia than non-drinkers. However, there is no study having assessed the influence of long-term high-risk drinking (LTHRD) on the effective doses of propofol for successful insertion of gastroscope with sedation. This study was designed to compare the effective doses of propofol for successful insertion of gastroscope between LTHRD and non-drinking (ND) Chinese male patients.
Thirty-one LTHRD patients and 29 ND male patients undergoing elective gastroscopy with propofol sedation were enrolled. The modified Dixon's up-and-down method was applied to determine the calculated median effective dose (ED) of propofol for successful insertion of gastroscope. Furthermore, the isotonic regression analysis was used to establish the dose-response curve of propofol and assess the effective doses of propofol where 50% (ED) and 95% (ED) of gastroscope insertions were successful.
The calculated ED of propofol for successful insertion of gastroscope was 1.55 ± 0.10 mg/kg and 1.44 ± 0.11 mg/kg in the LTHRD and ND patients. The isotonic regression analysis further showed that ED and ED of propofol for successful insertion of gastroscope was 1.50 mg/kg (95%CI, 1.40-1.63) and 1.80 mg/kg (95%CI, 1.74-1.90) in the LTHRD patients, respectively; 1.40 mg/kg (95% CI, 1.27-1.57) and 1.60 mg/kg (95%CI, 1.56-1.65) in the ND patients. The ED of propofol for successful insertion of gastroscope was not significantly different between LTHRD and ND patients.
This study demonstrates that the difference in the estimated ED of propofol for successful insertion of gastroscope between LTHRD and ND Chinese male patients was not statistically significant.
The study was registered on November 28, 2020 ( ChiCTR2000040382 ) in the Chinese Clinical Trial Registry.
现有文献表明，长期饮酒者在接受麻醉诱导时需要更高剂量的异丙酚，而非饮酒者则无需如此。然而，目前尚无研究评估长期高危饮酒（LTHRD）对镇静下成功插入胃镜所需异丙酚有效剂量的影响。本研究旨在比较 LTHRD 和非饮酒（ND）中国男性患者在成功插入胃镜时所需异丙酚的有效剂量。
本研究共纳入 31 例 LTHRD 患者和 29 例 ND 男性患者，均接受异丙酚镇静下的择期胃镜检查。采用改良 Dixon 上下法确定异丙酚成功插入胃镜的计算中位有效剂量（ED）。此外，采用等张回归分析建立异丙酚的剂量-反应曲线，并评估 50%（ED）和 95%（ED）成功插入胃镜时异丙酚的有效剂量。
LTHRD 和 ND 患者成功插入胃镜时异丙酚的计算 ED 分别为 1.55±0.10mg/kg 和 1.44±0.11mg/kg。等张回归分析进一步显示，LTHRD 患者成功插入胃镜时的 ED 和 ED 分别为 1.50mg/kg（95%CI，1.40-1.63）和 1.80mg/kg（95%CI，1.74-1.90）；ND 患者的 ED 和 ED 分别为 1.40mg/kg（95%CI，1.27-1.57）和 1.60mg/kg（95%CI，1.56-1.65）。LTHRD 和 ND 患者成功插入胃镜时异丙酚的 ED 无显著差异。
本研究表明，LTHRD 和 ND 中国男性患者成功插入胃镜时异丙酚的 ED 估计值存在差异，但无统计学意义。
本研究于 2020 年 11 月 28 日在中国临床试验注册中心注册（ ChiCTR2000040382 ）。
