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儿童和青少年双相情感障碍的临床实践研究现状

Research Status in Clinical Practice Regarding Pediatric and Adolescent Bipolar Disorders.

作者信息

Liu Lu, Meng Ming, Zhu Xiaotong, Zhu Gang

机构信息

Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, China.

Department of Psychiatry, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.

出版信息

Front Psychiatry. 2022 May 27;13:882616. doi: 10.3389/fpsyt.2022.882616. eCollection 2022.

Abstract

Bipolar disorders (BDs) have high morbidity. The first onset of 27.7% of BDs occurs in children under 13 years and of 37.6% occurs in adolescents between 13 and 18 years. However, not all of the pediatric and adolescent patients with BD receive therapy in time. Therefore, studies about pediatric and adolescent patients with disorders have aroused increased attention in the scientific community. Pediatric and adolescent patients with BD present with a high prevalence rate (0.9-3.9%), and the pathogenic factors are mostly due to genetics and the environment; however, the pathological mechanisms remain unclear. Pediatric and adolescent patients with BD manifest differently from adults with BDs and the use of scales can be helpful for diagnosis and treatment evaluation. Pediatric and adolescent patients with BDs have been confirmed to have a high comorbidity rate with many other kinds of disorders. Both medication and psychological therapies have been shown to be safe and efficient methods for the treatment of BD. This review summarizes the research status related to the epidemiology, pathogenic factors, clinical manifestations, comorbidities, diagnostic and treatment scales, medications, and psychological therapies associated with BDs.

摘要

双相情感障碍(BDs)发病率很高。27.7%的双相情感障碍首次发病于13岁以下儿童,37.6%发病于13至18岁青少年。然而,并非所有双相情感障碍的儿科和青少年患者都能及时接受治疗。因此,关于患有双相情感障碍的儿科和青少年患者的研究在科学界引起了越来越多的关注。患有双相情感障碍的儿科和青少年患者患病率很高(0.9 - 3.9%),致病因素主要是遗传和环境;然而,其病理机制仍不清楚。患有双相情感障碍的儿科和青少年患者与成年双相情感障碍患者表现不同,使用量表有助于诊断和治疗评估。已证实患有双相情感障碍的儿科和青少年患者与许多其他类型疾病的共病率很高。药物治疗和心理治疗均已被证明是治疗双相情感障碍的安全有效方法。本综述总结了与双相情感障碍相关的流行病学、致病因素、临床表现、共病情况、诊断和治疗量表、药物治疗以及心理治疗的研究现状。

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