Fan Xing, Xia Liye, Zhou Zheng, Qiu Yanyan, Zhao Chenhao, Yin Xiaomin, Qian Wei
Department of Biochemistry and Molecular Biology, Medical School, Jiangsu Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education of China, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China.
NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, Nantong, China.
Front Aging Neurosci. 2022 May 27;14:908881. doi: 10.3389/fnagi.2022.908881. eCollection 2022.
Alzheimer's disease (AD) is characterized by two pathological features: neurofibrillary tangles (NFTs), formed by microtubule-associated protein tau, and abnormal accumulation of amyloid-β (Aβ). Multiple evidence placed synaptic tau as the vital fact of AD pathology, especially at the very early stage of AD. In the present review, we discuss tau phosphorylation, which is critical for the dendritic localization of tau and synaptic plasticity. We review the related kinases and phosphatases implicated in the synaptic function of tau. We also review the synergistic effects of these kinases and phosphatases on tau-associated synaptic deficits. We aim to open a new perspective on the treatment of AD.
阿尔茨海默病（AD）具有两种病理特征：由微管相关蛋白tau形成的神经原纤维缠结（NFTs），以及淀粉样β蛋白（Aβ）的异常积累。多项证据表明，突触中的tau是AD病理的关键因素，尤其是在AD的极早期阶段。在本综述中，我们讨论了tau磷酸化，它对于tau在树突中的定位和突触可塑性至关重要。我们回顾了与tau突触功能相关的激酶和磷酸酶。我们还回顾了这些激酶和磷酸酶对tau相关突触缺陷的协同作用。我们旨在为AD的治疗开辟一个新的视角。
