Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60612, United States.
Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, IL, 60612, United States.
Phytochemistry. 2022 Sep;201:113276. doi: 10.1016/j.phytochem.2022.113276. Epub 2022 Jun 15.
From the stem bark of Entandrophragma angolense, six undescribed compounds were isolated, including seco-tirucallane type triterpenoids, limonoids, and a catechin glucoside, along with nineteen known structures. All structures were determined by interpretation of spectroscopic and HRMS data, and absolute configuration was confirmed with the aid of electronic circular dichroism. The isolated compounds were tested for LPS-induced NO inhibition in RAW 264.7 macrophages and EC values for moluccensin O and (-)-catechin were 81 μM and 137 μM, respectively.
从安哥拉榄仁树的树皮中分离得到了六种未知化合物，包括甾体三萜、柠檬苦素和儿茶素糖苷，以及十九种已知结构。所有结构均通过光谱和高分辨质谱数据的解析确定，绝对构型借助电子圆二色谱确定。对分离得到的化合物进行了 LPS 诱导的 RAW 264.7 巨噬细胞中 NO 抑制活性测试，结果表明 moluccensin O 和 (-)-儿茶素的 EC50 值分别为 81 μM 和 137 μM。
