从安哥拉榄仁树中提取的柠檬苦素和其他三萜类化合物。
Limonoids and other triterpenoids from Entandrophragma angolense.
机构信息
Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, United States.
Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, United States; Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
出版信息
Fitoterapia. 2021 Apr;150:104846. doi: 10.1016/j.fitote.2021.104846. Epub 2021 Feb 12.
Four new compounds (1-4) were isolated from the stem bark of Entandrophragma angolense along with eleven known structures (5-15). The chemical structures were elucidated on the basis of spectroscopic and HRMS data, and the absolute configuration was established with the aid of electronic circular dichroism. Compound 5 displayed moderate cytotoxicity against MDA-MB-231, OVCAR3, MDA-MB-435, and HT29 cell lines, with IC values ranging from 2.0-5.9 μM.
从安哥拉榄仁树的茎皮中分离得到了四个新化合物（1-4），以及十一个已知结构的化合物（5-15）。根据光谱和高分辨质谱数据阐明了这些化合物的化学结构，并借助电子圆二色谱确定了它们的绝对构型。化合物 5 对 MDA-MB-231、OVCAR3、MDA-MB-435 和 HT29 细胞系表现出中等的细胞毒性，IC 值范围为 2.0-5.9 μM。
Zotero 插件