Masdrakis Vasilios G, Papageorgiou Charalambos, Markianos Manolis
First Department of Psychiatry, School of Medicine, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Nord J Psychiatry. 2023 Apr;77(3):221-226. doi: 10.1080/08039488.2022.2083675. Epub 2022 Jun 17.
The potential association between oxytocin (OXT) plasma levels and clinical and hormonal parameters in panic disorder (PD) especially in its acute phase - has not been investigated as yet. This was the aim of this article.
Twenty-four consecutively-referred, acutely-ill, medication-free PD patients with (PDA, = 21) or without agoraphobia, moreover without comorbidities, completed the following clinical measures: Hamilton Anxiety Rating Scale (HARS); Agoraphobic Cognitions Questionnaire (ACQ); Mobility Inventory-Alone subscale (MI-alone); and number of panic attacks during last 21 d (PA21d). Plasma levels of OXT, adrenocorticotropic hormone (ACTH) and cortisol were evaluated.
OXT levels were significantly, negatively associated with the HARS scores (= -0.59 =.002) and weakly, negatively correlated with the ACQ scores ( = -0.403 =.051). No significant correlations were traced between OXT levels and PA21d, MI-alone, ACTH, and cortisol.
In acutely-ill, medication-free PD patients, OXT plasma levels may be relevant to the severity of their 'general' anxiety symptoms, but not to the 'specific' panic psychopathology.
目前尚未研究过恐慌症（PD）尤其是急性期患者血浆中催产素（OXT）水平与临床及激素参数之间的潜在关联。本文旨在对此进行研究。
连续纳入24例急性发病、未服用药物的PD患者，其中伴有广场恐惧症（PDA，n = 21）或不伴有广场恐惧症，且无合并症，完成以下临床测量：汉密尔顿焦虑量表（HARS）；广场恐惧症认知问卷（ACQ）；活动量表-独自分量表（MI-独自）；以及过去21天内的恐慌发作次数（PA21d）。评估血浆中OXT、促肾上腺皮质激素（ACTH）和皮质醇的水平。
OXT水平与HARS评分显著负相关（r = -0.59，P = 0.002），与ACQ评分呈弱负相关（r = -0.403，P = 0.051）。OXT水平与PA21d、MI-独自、ACTH和皮质醇之间未发现显著相关性。
在急性发病、未服用药物的PD患者中，血浆OXT水平可能与“一般性”焦虑症状的严重程度相关，但与“特异性”恐慌心理病理学无关。
