Laboratoire de Biologie des Ligneux et des Grandes Cultures (LBLGC), Université d'Orléans, UPRES EA 1207-USC INRAE 1328, 1 rue de Chartres, BP 6759, 45067 Orléans, France.
Laboratoire de Biologie des Ligneux et des Grandes Cultures (LBLGC), Université d'Orléans, UPRES EA 1207-USC INRAE 1328, 1 rue de Chartres, BP 6759, 45067 Orléans, France.
Pestic Biochem Physiol. 2022 Jun;184:105126. doi: 10.1016/j.pestbp.2022.105126. Epub 2022 May 16.
Synthetic insecticides continue to be the main strategy for managing insect pests, which are a major concern for both crop protection and public health. As nicotinic acetylcholine receptors play a central role in insect neurotransmission, they are the molecular target of neurotoxic insecticides such as neonicotinoids. These insecticides are used worldwide and have shown high efficiency in culture protection. However, the emergence of insect resistance mechanisms, and negative side-effects on non-target species have highlighted the need for a new control strategy. In this context, the use of insecticide mixtures with synergistic effects have been used in order to decrease the insecticide dose, and thus delay the selection of resistance-strains, and limit their negative impact. In this review, we summarize the available data concerning the mode of action of neonicotinoid mixtures, as well as their toxicity to various insect pests and non-target species. We found that insecticide mixtures containing neonicotinoids may be an effective strategy for limiting insect pests, and in particular resistant strains, although they could also negatively impact non-target species such as pollinating insects.
合成杀虫剂仍然是防治害虫的主要策略，这是作物保护和公共卫生的主要关注点。由于烟碱型乙酰胆碱受体在昆虫神经传递中起着核心作用，因此它们是新烟碱类等神经毒杀虫剂的分子靶标。这些杀虫剂在全世界范围内使用，并在文化保护方面显示出了很高的效率。然而，昆虫抗药性机制的出现以及对非目标物种的负面影响，凸显了需要新的控制策略。在这种情况下，使用具有协同作用的杀虫剂混合物已被用于降低杀虫剂剂量，从而延迟抗性菌株的选择，并限制其负面影响。在这篇综述中，我们总结了有关新烟碱类混合物作用模式的现有数据，以及它们对各种害虫和非目标物种的毒性。我们发现，含有新烟碱类的杀虫剂混合物可能是限制害虫，特别是抗性菌株的有效策略，尽管它们也可能对传粉昆虫等非目标物种产生负面影响。
