The use of insecticide mixtures containing neonicotinoids as a strategy to limit insect pests: Efficiency and mode of action.

Synthetic insecticides continue to be the main strategy for managing insect pests, which are a major concern for both crop protection and public health. As nicotinic acetylcholine receptors play a central role in insect neurotransmission, they are the molecular target of neurotoxic insecticides such as neonicotinoids. These insecticides are used worldwide and have shown high efficiency in culture protection. However, the emergence of insect resistance mechanisms, and negative side-effects on non-target species have highlighted the need for a new control strategy. In this context, the use of insecticide mixtures with synergistic effects have been used in order to decrease the insecticide dose, and thus delay the selection of resistance-strains, and limit their negative impact. In this review, we summarize the available data concerning the mode of action of neonicotinoid mixtures, as well as their toxicity to various insect pests and non-target species. We found that insecticide mixtures containing neonicotinoids may be an effective strategy for limiting insect pests, and in particular resistant strains, although they could also negatively impact non-target species such as pollinating insects.