Baculovirus-Based Biocontrol: Synergistic and Antagonistic Interactions of PxGV, PxNPV, SeMNPV, and SfMNPV in Integrative Pest Management.

The use of chemical pesticides in agriculture has led to the development of resistant pest populations, posing a challenge to long-term pest management. This review aims to evaluate the scientific literature on the individual and combined use of baculoviruses with conventional chemical and biological insecticides to combat , , and in broccoli, tomato, and maize crops. Notable findings include that both individual nucleopolyhedrovirus (PxNPV) and the combination of granulovirus (PxGV) and azadirachtin at a low dose effectively control both combinations of multiple nucleopolyhedrovirus (SeMNPV) with emamectin benzoate and chlorfenapyr reduced resistance in and increased the efficacy of the insecticides; and the combination of nucleopolyhedrovirus (SfMNPV) and spinetoram is effective against Integrating baculoviruses into pest management strategies offers a promising approach to mitigate the adverse effects of chemical pesticides, such as resistance development, health risks, and environmental damage. However, there remains a broad spectrum of research opportunities regarding the use of baculoviruses in agriculture.