Department of Geriatrics and Gerontology, National Taiwan University Hospital, Taipei, 100, Taiwan.
Research & Design Center, TCI CO., Ltd., Taipei, 114, Taiwan.
J Biomed Nanotechnol. 2022 Mar 1;18(3):922-927. doi: 10.1166/jbn.2022.3274.
Vitamin C is an important antioxidant in the human body that plays a role in many body functions. Liposomal encapsulation is a technology commonly used in food processing and medicine. This study determines whether Double Nutri (liposomal encapsulation) increases the absorption rate for vitamin C supplementation. Subjects enrolled in this study took vitamin C without liposome; then, 14 d washout was given with liposomal process A vitamin C. After 14 d washout, the subjects took liposomal process B vitamin C (Double Nutri) was given. After taking the test sample, the vitamin C concentration in venous blood was measured from the baseline (0 h), 0.5, 1, 2, 3, 4, and 8 h. Eleven healthy subjects were recruited for three tests. The vitamin C concentration for liposomal process B vitamin C (Double Nutri) group is higher (7.26±3.52, <0.01) than that for the liposomal process A vitamin C group (6.41±3.80, <0.05) and for vitamin C without liposome (2.21±4.07). This shows that Double Nutri has better bioavailability and can last up in the body to 8 hours. In addition, this study shows that Double Nutri increases the half-life of vitamin C in plasma and has higher bioavailability.
维生素 C 是人体内一种重要的抗氧化剂，在许多身体功能中发挥作用。脂质体包封是一种常用于食品加工和医药的技术。本研究旨在确定 Double Nutri（脂质体包封）是否能提高维生素 C 补充剂的吸收率。本研究的受试者服用了不含脂质体的维生素 C；然后，用 A 型脂质体过程维生素 C 进行 14 天洗脱期。14 天洗脱期后，受试者服用 B 型脂质体过程维生素 C（Double Nutri）。服用测试样品后，从基线（0 h）、0.5、1、2、3、4 和 8 h 测量静脉血中维生素 C 浓度。招募了 11 名健康受试者进行了三项测试。B 型脂质体过程维生素 C（Double Nutri）组的维生素 C 浓度较高（7.26±3.52，<0.01），高于 A 型脂质体过程维生素 C 组（6.41±3.80，<0.05）和不含脂质体的维生素 C 组（2.21±4.07）。这表明 Double Nutri 具有更好的生物利用度，并且可以在体内持续 8 小时。此外，本研究表明 Double Nutri 增加了血浆中维生素 C 的半衰期，具有更高的生物利用度。
