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结核分枝杆菌分子细菌载量检测揭示复发性结核病患者早期细菌清除延迟。

Tuberculosis Molecular Bacterial Load Assay Reveals Early Delayed Bacterial Killing in Patients With Relapse.

机构信息

National Institute for Medical Research-Mbeya Medical Research Centre, Mbeya, United Republic of Tanzania.

Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, Munich, Germany.

出版信息

Clin Infect Dis. 2023 Feb 8;76(3):e990-e994. doi: 10.1093/cid/ciac445.

DOI:10.1093/cid/ciac445
PMID:35717643
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9907486/
Abstract

Bacterial killing in patients with tuberculosis (TB) relapse was compared to that in patients achieving cure, measured by TB molecular bacterial load assay (TB-MBLA) or mycobacteria growth indicator tube (MGIT) time to positivity (TTP). TB-MBLA in 4 relapsed patients was significantly different compared to 132 cured patients after 2 weeks of treatment; MGIT TTP showed a significant difference from week 8.

摘要

比较了结核（TB）复发患者和获得治愈的患者的细菌清除率，通过结核分子细菌负荷检测（TB-MBLA）或分枝杆菌生长指示管（MGIT）阳性时间（TTP）来衡量。与 132 例治愈患者相比，4 例复发患者在治疗 2 周后 TB-MBLA 显著不同；MGIT TTP 在第 8 周时显示出显著差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee05/9907486/803dd666a09a/ciac445f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee05/9907486/803dd666a09a/ciac445f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee05/9907486/803dd666a09a/ciac445f1.jpg

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2
A patient-level pooled analysis of treatment-shortening regimens for drug-susceptible pulmonary tuberculosis.药物敏感性肺结核治疗缩短方案的患者水平汇总分析。
Nat Med. 2018 Nov;24(11):1708-1715. doi: 10.1038/s41591-018-0224-2. Epub 2018 Nov 5.
3
Mycobacterial Load Assay.
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