Granek E, Baker S P, Abbey H, Robinson E, Myers A H, Samkoff J S, Klein L E
J Am Geriatr Soc. 1987 Jun;35(6):503-11. doi: 10.1111/j.1532-5415.1987.tb01395.x.
The association between falls, drugs, and diagnoses in elderly residents of a long-term care facility was explored using case-control methodology. The odds of being a faller rather than a control were significant (P less than .01) for those taking antidepressants, sedatives/hypnotics, or vasodilators, and for those with osteoarthritis or depression. When drug/diagnosis subgroups were examined, these same drug classes and diagnoses had high-odds ratios in the largest numbers of subgroups. In general, risk of falling appeared to be more strongly associated with drugs than with diagnoses.
采用病例对照研究方法，探讨了长期护理机构老年居民跌倒、药物使用和诊断之间的关联。服用抗抑郁药、镇静剂/催眠药或血管扩张剂的患者以及患有骨关节炎或抑郁症的患者，相较于对照组，跌倒的几率显著增加（P<0.01）。在对药物/诊断亚组进行检查时，这些相同的药物类别和诊断在大多数亚组中具有较高的优势比。总体而言，跌倒风险似乎与药物的关联比与诊断的关联更强。
