Onai T, Takayama K, Miura M
J Auton Nerv Syst. 1987 Feb;18(2):163-75. doi: 10.1016/0165-1838(87)90103-2.
Using chloralose-anesthetized cats, afferent projections to the nucleus tractus solitarii (NTS) were studied in relation to circulatory and respiratory responses. Horseradish peroxidase (HRP) was injected into 3 distinct regions of the NTS: the rostral regions from which electrical stimulation elicited pressor and apneustic responses: the intermediate regions from which stimulation elicited depressor and apneic responses; the commissure regions from which stimulation elicited depressor and hypopneic responses. HRP-labeled cells were sought throughout the medulla oblongata upward including the telencephalon. The results indicate that: many neurons of the frontal cortex (sigmoid gyrus, anterior ectosylvian gyrus, anterior sylvian gyrus, and anterior suprasylvian gyrus) project bilaterally to the 3 regions, predominantly to the rostral regions; a few neurons of the bed nucleus of the stria terminalis project almost ipsilaterally to the 3 regions; a few neurons of the nucleus amygdalae centralis project almost ipsilaterally to the 3 regions; many neurons of the paraventricular nucleus project bilaterally to the 3 regions, predominantly to the ipsilateral commissure regions; a moderate number of neurons of the fastigial nucleus project contralaterally to the rostral regions. These findings suggest that there are some specific projections to each region of the NTS from various supramedullary nuclei, which may be involved in modulation of the cardiovascular and respiratory systems.
利用水合氯醛麻醉的猫，研究了孤束核（NTS）的传入投射与循环和呼吸反应的关系。将辣根过氧化物酶（HRP）注入NTS的3个不同区域：电刺激引发升压和长吸反应的吻侧区域；刺激引发降压和呼吸暂停反应的中间区域；刺激引发降压和呼吸浅慢反应的连合区域。在整个延髓向上直至端脑寻找HRP标记的细胞。结果表明：额叶皮质（乙状回、外侧前回、西尔维乌斯前回和西尔维乌斯上回）的许多神经元双侧投射到这3个区域，主要投射到吻侧区域；终纹床核的少数神经元几乎同侧投射到这3个区域；杏仁中央核的少数神经元几乎同侧投射到这3个区域；室旁核的许多神经元双侧投射到这3个区域，主要投射到同侧连合区域；顶核的中等数量神经元对侧投射到吻侧区域。这些发现表明，来自各种延髓上核的一些特定投射到NTS的每个区域，这可能参与心血管和呼吸系统的调节。
