The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia; Clinician Investigator Program, University of British Columbia, Vancouver, Canada; Division of Nephrology, University of British Columbia, Vancouver, British Columbia, Canada.
Division of Nephrology, University of British Columbia, Vancouver, British Columbia, Canada; BC Renal, Provincial Health Services Authority, Vancouver, British Columbia, Canada.
Semin Nephrol. 2022 Mar;42(2):197-207. doi: 10.1016/j.semnephrol.2022.04.009.
This review on sex, gender, and cardiovascular diseases in chronic kidney disease attempts to summarize what we know and what we do not know about the effects of sex and gender on cardiovascular disease in chronic kidney disease. We discuss and define the terminology of sex and gender, and the underlying physiology for differences observed. We explore how sex and gender affect specific cardiovascular diseases such as coronary artery disease, congestive heart failure, arrhythmias, cardiovascular mortality, and pre-eclampsia. We conclude with a review of recent randomized controlled trials and highlight the pharmacokinetic and pharmacodynamic differences in both sexes.
这篇关于慢性肾脏病中心血管疾病的性别和性别差异的综述，旨在总结我们对性别差异影响慢性肾脏病中心血管疾病的认识，讨论并定义了性别和性别差异的术语，并探讨了观察到的差异的潜在生理学机制。我们还探讨了性别如何影响特定的心血管疾病，如冠状动脉疾病、充血性心力衰竭、心律失常、心血管死亡率和子痫前期。最后，我们回顾了最近的随机对照试验，并强调了两性之间在药代动力学和药效学方面的差异。
