Department of Biomedical, Surgical and Dental Sciences, University of Milano, Milan, Italy; IRCCS Orthopedic Institute Galeazzi, Dental Clinic, Milano, Italy; Department of Oral Surgery, Institute of Dentistry, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
Department of Biomedical, Surgical and Dental Sciences, University of Milano, Milan, Italy; Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara "Gabriele D'Annunzio", Chieti, Italy.
J Evid Based Dent Pract. 2022 Jun;22(2):101709. doi: 10.1016/j.jebdp.2022.101709. Epub 2022 Feb 26.
Previous studies demonstrated a dose-dependent efficacy of sodium bicarbonate when added to dentifrices for the mechanical control of dental biofilm. The present systematic review and meta-analysis aimed to evaluate the efficacy of a 67% sodium bicarbonate-based toothpaste for gingival health parameters improvement in subjects with gingivitis.
An electronic search on MEDLINE, Scopus, and Cochrane Central Register of Controlled Trials (CENTRAL), was performed using a combination of keywords, followed by a hand search on pertinent Journals. Randomized controlled trials (RCTs) and prospective comparative studies in English language were included. There was no publication date and language restriction. The data regarding gingival, bleeding, and plaque index were extracted from the selected studies. Included studies underwent risk-of-bias assessment. When at least 3 studies reporting the same outcome were found, a meta-analysis was undertaken, to estimate the combined effect. Trial Sequential Analysis (TSA) was also performed to evaluate the power of the meta-analysis for primary outcomes.
The search strategy yielded 83 articles. After screening, 7 RCTs were included. Three were at high risk, one at moderate risk, and 3 at low risk-of-bias. Significant improvement of gingival index, bleeding index, and plaque index was observed in patients using 67% sodium bicarbonate toothpaste as compared with control subjects. TSA showed sufficient power for modified Gingival index and bleeding scores.
The clinical use of 67% sodium bicarbonate toothpaste can improve periodontal health in patients with gingivitis.
先前的研究表明，在牙膏中添加碳酸氢钠可产生剂量依赖性效果，有助于机械控制牙菌斑。本系统评价和荟萃分析旨在评估 67%碳酸氢钠基牙膏对牙龈炎患者改善牙龈健康参数的疗效。
通过组合关键词，在 MEDLINE、Scopus 和 Cochrane 对照试验中心注册 (CENTRAL) 上进行电子检索，然后对相关期刊进行手工检索。纳入英语随机对照试验 (RCT) 和前瞻性对照研究。无发表日期和语言限制。从选定的研究中提取关于牙龈、出血和菌斑指数的数据。纳入的研究进行了偏倚风险评估。当发现至少有 3 项报告相同结果的研究时，进行荟萃分析以估计综合效果。还进行了试验序贯分析 (TSA) 以评估主要结局的荟萃分析的功效。
搜索策略产生了 83 篇文章。经过筛选，纳入了 7 项 RCT。其中 3 项为高风险，1 项为中风险，3 项为低风险。与对照组相比，使用 67%碳酸氢钠牙膏的患者的牙龈指数、出血指数和菌斑指数均显著改善。TSA 显示改良牙龈指数和出血评分的功效足够。
临床使用 67%碳酸氢钠牙膏可改善牙龈炎患者的牙周健康。
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