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通过微流控模拟、实验验证和电阻抗光谱法分析牙膏中的共聚物颗粒

Analysis of Covarine Particle in Toothpaste Through Microfluidic Simulation, Experimental Validation, and Electrical Impedance Spectroscopy.

作者信息

Đoćoš Miroslav, Thiha Aung, Vejin Marija, Movrin Dejan, Jamaluddin Nurul Fauzani, Kojić Sanja, Petrović Bojan, Ibrahim Fatimah, Stojanović Goran

机构信息

Faculty of Technical Sciences, University of Novi Sad, Trg Dositeja Obradovića 6, Novi Sad 21000, Serbia.

Centre for Innovation in Medical Engineering (CIME), Faculty of Engineering, Universiti Malaya, Kuala Lumpur 50603, Malaysia.

出版信息

ACS Omega. 2024 Feb 23;9(9):10539-10555. doi: 10.1021/acsomega.3c08799. eCollection 2024 Mar 5.

DOI:10.1021/acsomega.3c08799
PMID:38463280
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10918793/
Abstract

Covarine, copper phthalocyanine, a novel tooth whitening ingredient, has been incorporated into various toothpaste formulations using diverse technologies such as larger flakes, two-phase pastes, and microbeads. In this study, we investigated the behavior of covarine microbeads (200 μm) in Colgate advanced white toothpaste when mixed with artificial and real saliva. Our analysis utilized a custom-designed microfluidic mixer with 400 μm wide channels arranged in serpentine patterns, featuring a Y-shaped design for saliva and toothpaste flow. The mixer, fabricated using stereolithography 3D printing technology, incorporated a flexible transparent resin (Formlabs' Flexible 80A resin) and PMMA layers. COMSOL simulations were performed by utilizing parameters extracted from toothpaste and saliva datasheets, supplemented by laboratory measurements, to enhance simulation accuracy. Experimental assessments encompassing the behavior of covarine particles were conducted using an optical profilometer. Viscosity tests and electrical impedance spectroscopy employing recently developed all-carbon electrodes were employed to analyze different toothpaste dilutions. The integration of experimental data from microfluidic chips with computational simulations offers thorough insights into the interactions of covarine particles with saliva and the formation of microfilms on enamel surfaces.

摘要

新型牙齿美白成分铜酞菁（Covarine）已通过多种技术被添加到各种牙膏配方中，这些技术包括较大的薄片、两相膏体和微珠。在本研究中，我们研究了高露洁高级美白牙膏中铜酞菁微珠（200μm）与人工唾液和真实唾液混合时的行为。我们的分析使用了一种定制设计的微流体混合器，其具有以蛇形图案排列的400μm宽的通道，采用Y形设计用于唾液和牙膏流动。该混合器采用立体光刻3D打印技术制造，包含柔性透明树脂（Formlabs的Flexible 80A树脂）和PMMA层。通过利用从牙膏和唾液数据表中提取的参数并辅以实验室测量来进行COMSOL模拟，以提高模拟精度。使用光学轮廓仪对包含铜酞菁颗粒行为的实验评估进行了研究。采用最近开发的全碳电极进行粘度测试和电阻抗谱分析不同的牙膏稀释液。将微流体芯片的实验数据与计算模拟相结合，能够深入了解铜酞菁颗粒与唾液的相互作用以及牙釉质表面微膜的形成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58f5/10918793/e83f55cc2533/ao3c08799_0011.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58f5/10918793/71e3e45c26c7/ao3c08799_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58f5/10918793/3379649a2451/ao3c08799_0008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58f5/10918793/e83f55cc2533/ao3c08799_0011.jpg

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