Zhang Bu-Xin, Wang Li, Wang Qing-Xing, Tu Yuan-Hui, Li Jing
Department of Dermatology, Henan Province Hospital of Traditional Chinese Medicine (Second Affiliated Hospital of Henan University of Chinese Medicine) Zhengzhou 450002, China.
Zhongguo Zhong Yao Za Zhi. 2022 Jun;47(11):3105-3110. doi: 10.19540/j.cnki.cjcmm.20220222.501.
The present study observed the clinical effect of modified Yiyi Baijiang Decoction on psoriasis vulgaris and explored its influence on growth factors and inflammatory factors in the serum and skin tissues. A total of 130 patients were randomly divided into control group and experimental group, with 65 cases in each group. The patients in the control group received Acitretin Capsules and Calcipotriol Ointment, and those in the experimental group received modified Yiyi Baijiang Decoction combined with external application for four weeks. The psoriasis area and severity index(PASI), blood vessel count in the superficial dermis(SDBVC), skin thickness(STK), and traditional Chinese medicine(TCM) symptoms were observed before and after treatment. The growth factors [epidermal growth factor(EGF), endothelial cell-specific molecule-1(ESM-1), fibroblast growth factor-23(FGF-23), and transforming growth factor-β1(TGF-β1)] and inflammatory factors [nuclear factor-κB(NF-κB), prealbumin(PA), CC chemokine ligand 20(CCL20), and procalcitonin(PCT)] in the serum and skin tissues were detected. The total effective rate was 98.5% in the experimental group, higher than that 83.1% in the control group(P<0.05). Compared with the control group after treatment, the experimental group showed decreased PASI, SDBVC, STK, TCM symptoms, ESM-1, FGF-23, TGF-β1, NF-κB, CCL20, and PCT(P<0.05), and increased EGF and PA(P<0.05). The incidence of adverse events was 1.5% in the experimental group, lower than that 21.5% in the control group(P<0.05). The results showed that modified Yiyi Baijiang Decoction could effectively relieve skin lesions in patients with psoriasis vulgaris and improve the growth factors and inflammatory factors in the serum and skin lesions, with high safety.
本研究观察了加味薏苡败酱汤治疗寻常型银屑病的临床疗效，并探讨其对血清及皮肤组织中生长因子和炎症因子的影响。将130例患者随机分为对照组和试验组，每组65例。对照组患者服用阿维A胶囊和卡泊三醇软膏，试验组患者服用加味薏苡败酱汤并外用，疗程均为4周。观察治疗前后的银屑病面积和严重程度指数（PASI）、浅表真皮血管计数（SDBVC）、皮肤厚度（STK）及中医症状。检测血清及皮肤组织中的生长因子[表皮生长因子（EGF）、内皮细胞特异性分子-1（ESM-1）、成纤维细胞生长因子-23（FGF-23）和转化生长因子-β1（TGF-β1）]和炎症因子[核因子-κB（NF-κB）、前白蛋白（PA）、CC趋化因子配体20（CCL20）和降钙素原（PCT）]。试验组总有效率为98.5%，高于对照组的83.1%（P＜0.05）。与治疗后的对照组相比，试验组的PASI、SDBVC、STK、中医症状、ESM-1、FGF-23、TGF-β1、NF-κB、CCL20和PCT降低（P＜0.05），EGF和PA升高（P＜0.05）。试验组不良事件发生率为1.5%，低于对照组的21.5%（P＜0.05）。结果表明，加味薏苡败酱汤可有效缓解寻常型银屑病患者的皮损症状，改善血清及皮损中的生长因子和炎症因子，安全性高。
