Veterans Affairs Medical Center, Mather, CA, United States of America.
UT Southwestern Medical Center, Dallas, TX, United States of America.
J Diabetes Complications. 2022 Jul;36(7):108231. doi: 10.1016/j.jdiacomp.2022.108231. Epub 2022 Jun 15.
The ratio of triglycerides (TG) to high density lipoprotein-cholesterol (HDL-C) is a validated biomarker of insulin resistance and metabolic syndrome (MetS). In African-Americans (AA) there is concern about this ratio because their mean TG level is lower than the general population. As an alternative approach, we examined the CRP:HDL-C ratio in both AA and non-Hispanic whites (NHW) in the NHANES study for its association with MetS.
A total of n = 3541 individuals were studied from the NHANES data. Fasting blood samples were obtained for lipids, insulin, and CRP. TG and CRP ratios to HDL-C were calculated.
The TG:HDL-C ratio was significantly increased in NHW compared to AA, but the CRP:HDL-C ratio did not differ between NHW and AA groups. Both ratios were significantly increased in MetS patients versus controls (both races) and increased with greater severity of MetS. Receiver Operating Characteristic (ROC) curve analysis showed that the TG:HDL-C area under the curve was superior to CRP:HDL-C in predicting MetS in both AA and NHW patients.
In this large NHANES study, the TG:HDL-C ratio is a superior predictor of MetS in both AA and NHW persons despite the lower TG levels in AA persons.
甘油三酯（TG）与高密度脂蛋白胆固醇（HDL-C）的比值是胰岛素抵抗和代谢综合征（MetS）的有效生物标志物。在非裔美国人（AA）中，人们对这个比值表示担忧，因为他们的平均 TG 水平低于一般人群。作为一种替代方法，我们在 NHANES 研究中检查了 AA 和非西班牙裔白人（NHW）中的 CRP：HDL-C 比值，以研究其与 MetS 的相关性。
从 NHANES 数据中研究了总共 n=3541 名个体。采集空腹血样进行血脂、胰岛素和 CRP 检测。计算 TG 和 CRP 与 HDL-C 的比值。
与 AA 相比，NHW 的 TG：HDL-C 比值显著升高，但 NHW 和 AA 组之间的 CRP：HDL-C 比值没有差异。与对照组相比，MetS 患者的两种比值均显著升高（两种种族），且随着 MetS 严重程度的增加而升高。受试者工作特征（ROC）曲线分析显示，在 AA 和 NHW 患者中，TG：HDL-C 曲线下面积优于 CRP：HDL-C，用于预测 MetS。
在这项大型 NHANES 研究中，尽管 AA 人群的 TG 水平较低，但 TG：HDL-C 比值仍然是 AA 和 NHW 人群 MetS 的更好预测指标。
