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t等位基因与哺乳动物精子发生过程中减数分裂后基因表达的可能性。

t-Alleles and the possibility of post-meiotic gene expression during mammalian spermatogenesis.

作者信息

Erickson R P

出版信息

Fed Proc. 1978 Sep;37(11):2517-21.

PMID:357186
Abstract

Although there is strong evidence for post-meiotic RNA synthesis during spermatogenesis, definitive proof of haploid gene transcription is lacking. Segregation distortion in t-allele-bearing males provides evidence for post-meiotic gene expression since delayed mating experiments argue strongly that there are similar numbers of qualitatively different spermatozoa in ejaculates of males carrying moderately distorting t-alleles. Such post-meiotic transcription may not be infrequent but the intercellular bridges connecting spermatids would usually maintain gametic equivalence.

摘要

尽管有确凿证据表明精子发生过程中存在减数分裂后RNA合成,但缺乏单倍体基因转录的确切证据。携带t等位基因的雄性的分离畸变提供了减数分裂后基因表达的证据,因为延迟交配实验有力地表明,携带中度畸变t等位基因的雄性射精中存在数量相似但质量不同的精子。这种减数分裂后的转录可能并不罕见,但连接精子细胞的细胞间桥通常会维持配子的等效性。

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t-Alleles and the possibility of post-meiotic gene expression during mammalian spermatogenesis.t等位基因与哺乳动物精子发生过程中减数分裂后基因表达的可能性。
Fed Proc. 1978 Sep;37(11):2517-21.
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引用本文的文献

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Mamm Genome. 2025 Mar;36(1):38-51. doi: 10.1007/s00335-024-10076-x. Epub 2024 Oct 14.
2
Expression of lactate dehydrogenase isozyme X in haploid cells of pigeon testis.
Mol Cell Biochem. 1980 Apr 18;30(2):87-91. doi: 10.1007/BF00227922.
3
Quantitation of mRNAs during mouse spermatogenesis: protamine-like histone and phosphoglycerate kinase-2 mRNAs increase after meiosis.小鼠精子发生过程中mRNA的定量分析:类鱼精蛋白组蛋白和磷酸甘油酸激酶-2 mRNA在减数分裂后增加。
Proc Natl Acad Sci U S A. 1980 Oct;77(10):6086-90. doi: 10.1073/pnas.77.10.6086.
4
Generation of flagella by cultured mouse spermatids.培养的小鼠精子细胞鞭毛的生成。
J Cell Biol. 1984 Feb;98(2):619-28. doi: 10.1083/jcb.98.2.619.
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Analysis of male sterile mutations in the mouse using haploid stage expressed cDNA probes.利用单倍体阶段表达的cDNA探针分析小鼠中的雄性不育突变。
Nucleic Acids Res. 1984 May 25;12(10):4281-93. doi: 10.1093/nar/12.10.4281.
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Haploid expression of a unique c-abl transcript in the mouse male germ line.小鼠雄性生殖系中独特c-abl转录本的单倍体表达。
Mol Cell Biol. 1985 Jul;5(7):1791-4. doi: 10.1128/mcb.5.7.1791-1794.1985.
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The 6's and 17's of developmental mutants near the major histocompatibility complex: the mouse t-complex does not have a human equivalent.主要组织相容性复合体附近发育突变体的6号和17号染色体:小鼠t-复合体没有与之对应的人类染色体。
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