小鼠雄性生殖系中独特c-abl转录本的单倍体表达。
Haploid expression of a unique c-abl transcript in the mouse male germ line.
作者信息
Ponzetto C, Wolgemuth D J
出版信息
Mol Cell Biol. 1985 Jul;5(7):1791-4. doi: 10.1128/mcb.5.7.1791-1794.1985.
Abstract
RNA from immature mouse testes was shown to lack a low-molecular-weight c-abl transcript previously noted to be the predominant species in adult testes. The developmental pattern of appearance of this c-abl variant was determined by analyzing RNA obtained from purified populations of testicular cells in different stages of spermatogenesis. The appearance of the c-abl testicular variant was coincident with the entry of the germ cells into their haploid state and suggested that the regulated expression of this proto-oncogene may be important in the normal differentiation of the male germ line.
摘要
来自未成熟小鼠睾丸的RNA显示缺乏一种低分子量的c-abl转录本，该转录本先前被认为是成年睾丸中的主要类型。通过分析从处于不同精子发生阶段的纯化睾丸细胞群体中获得的RNA，确定了这种c-abl变体出现的发育模式。c-abl睾丸变体的出现与生殖细胞进入单倍体状态同时发生，这表明该原癌基因的调控表达可能在雄性生殖系的正常分化中起重要作用。
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