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FOXP4-AS1可能是人类癌症中一种潜在的预后生物标志物：一项荟萃分析和生物信息学分析

FOXP4-AS1 May be a Potential Prognostic Biomarker in Human Cancers: A Meta-Analysis and Bioinformatics Analysis.

作者信息

Zhang Guangming, Wang Yongfeng, Han Xiaoyong, Lu Tingting, Fu Liangyin, Jin Haojie, Yang Kehu, Cai Hui

机构信息

The First Clinical Medical College of Gansu University of Chinese Medicine (Gansu Provincial Hospital), Lanzhou, China.

Department of General Surgery Clinical Medical Center, Gansu Provincial Hospital, Lanzhou, China.

出版信息

Front Oncol. 2022 May 26;12:799265. doi: 10.3389/fonc.2022.799265. eCollection 2022.

DOI:10.3389/fonc.2022.799265
PMID:35719909
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9204280/
Abstract

BACKGROUND

Cancer is one of the leading causes of death worldwide. Early diagnosis can significantly lower cancer-related mortality. Studies have shown that the lncRNA Forkhead box P4 antisense RNA 1 (FOXP4-AS1) is aberrantly expressed in various solid tumors. A meta-analysis was performed to evaluate the correlation of FOXP4-AS1 with the prognosis of cancer patients and determine the clinical value of FOXP4-AS1 as a potential diagnostic marker.

METHODS

Correlational studies from the Web of Science, Embase, OVID, Cochrane and PubMed databases were screened (up to April 1, 2021). Meta-analysis was performed using Stata SE12.0 software.

RESULTS

Eleven original studies with 1,332 patients who were diagnosed with a solid cancer (nasopharyngeal carcinoma, hepatocellular carcinoma, colorectal cancer, gastric cancer, osteosarcoma, mantle cell lymphoma, prostate cancer, and pancreatic ductal adenocarcinoma) were included in the meta-analysis. High expression of FOXP4-AS1 was correlated with poor overall survival (OS) (HR = 1.77, 95% CI 1.29-2.44, < 0.001) and shorter disease-free survival (DFS) (HR = 1.66, 95% CI 1.01-2.72, = 0.044). Subgroup analysis based on sample size, follow-up time and Newcastle-Ottawa Scale (NOS) score revealed significant differences between FOXP4-AS1 levels and OS ( < 0.05). However, the expression level of FOXP4-AS1 was not significantly correlated with the OS of gastric cancer patients ( = 0.381). High expression of FOXP4-AS1 was predictive of a larger tumor size (OR = 3.82, 95% CI 2.3-6.3, < 0.001).

CONCLUSIONS

Overexpression of FOXP4-AS1 correlates with poor prognosis of cancer patients, and is a potential prognostic biomarker and therapeutic target.

SYSTEMATIC REVIEW REGISTRATION

PROSPERO, identifier CRD42021245267.

摘要

背景

癌症是全球主要死因之一。早期诊断可显著降低癌症相关死亡率。研究表明，长链非编码RNA叉头框P4反义RNA 1（FOXP4-AS1）在多种实体瘤中异常表达。进行了一项荟萃分析，以评估FOXP4-AS1与癌症患者预后的相关性，并确定FOXP4-AS1作为潜在诊断标志物的临床价值。

方法

筛选了来自Web of Science、Embase、OVID、Cochrane和PubMed数据库的相关性研究（截至2021年4月1日）。使用Stata SE12.0软件进行荟萃分析。

结果

荟萃分析纳入了11项原始研究，共1332例被诊断为实体癌（鼻咽癌、肝细胞癌、结直肠癌、胃癌、骨肉瘤、套细胞淋巴瘤、前列腺癌和胰腺导管腺癌）的患者。FOXP4-AS1高表达与总生存期（OS）较差相关（HR = 1.77，95%CI 1.29 - 2.44，P < 0.001），无病生存期（DFS）较短（HR = 1.66，95%CI 1.01 - 2.72，P = 0.044）。基于样本量、随访时间和纽卡斯尔-渥太华量表（NOS）评分的亚组分析显示，FOXP4-AS1水平与OS之间存在显著差异（P < 0.05）。然而，FOXP4-AS1的表达水平与胃癌患者的OS无显著相关性（P = 0.381）。FOXP4-AS1高表达预示肿瘤体积较大（OR = 3.82，95%CI 2.3 - 6.3，P < 0.001）。

结论

FOXP4-AS1过表达与癌症患者预后不良相关，是一种潜在的预后生物标志物和治疗靶点。

系统评价注册

PROSPERO，标识符CRD42021245267。

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