Kishimoto Yoshimi, Aoyama Masayuki, Saita Emi, Ohmori Reiko, Tanimoto Kojiro, Kondo Kazuo, Momiyama Yukihiko
Department of Food Science and Human Nutrition, Setsunan University, Osaka, Japan.
Department of Cardiology, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.
J Clin Med Res. 2022 May;14(5):202-208. doi: 10.14740/jocmr4730. Epub 2022 May 31.
Endosialin, also called tumor endothelial marker-1 or CD248, is a transmembrane glycoprotein that is suggested to play a role in inflammation as well as tumor progression. Endosialin expression was also reported to be upregulated in human atherosclerotic lesions. However, no study has reported blood endosialin levels in patients with coronary artery disease (CAD).
We investigated the association between plasma endosialin levels and the presence or severity of CAD in 376 patients who underwent elective coronary angiography for suspected CAD. The severity of CAD was represented as the numbers of stenotic coronary vessels and segments.
Of the 376 study patients, CAD was found in 210 patients (one-vessel disease (1-VD), n = 90; two-vessel disease (2-VD), n = 65; and three-vessel disease (3-VD), n = 55). Compared with 166 patients without CAD, 210 patients with CAD had higher C-reactive protein (CRP) levels (median 0.57 vs. 0.43 mg/L, P = 0.007). However, endosialin levels did not significantly differ between patients with and without CAD (0.91 vs. 0.92 ng/mL, P = 0.693). A stepwise increase in CRP levels was found depending on the number of > 50% stenotic vessels: 0.43 in CAD(-), 0.52 in 1-VD, 0.57 in 2-VD, and 0.58 mg/L in 3-VD (P = 0.019). No marked difference was found in endosialin levels among four groups of CAD(-), 1-VD, 2-VD, and 3-VD (0.92, 0.89, 0.98, and 0.87 ng/mL, respectively, P = 0.785). Moreover, no significant correlation was found between endosialin levels and the numbers of > 50% and > 25% stenotic segments or CRP levels. In multivariate analysis, endosialin levels were not a significant factor associated with CAD independent of atherosclerotic risk factors.
Plasma endosialin levels in patients with CAD were found to be not higher than in those without CAD and to be not significantly associated with the presence or severity of CAD.
内唾液酸蛋白，也称为肿瘤内皮标志物-1或CD248，是一种跨膜糖蛋白，被认为在炎症以及肿瘤进展中发挥作用。也有报道称内唾液酸蛋白在人类动脉粥样硬化病变中表达上调。然而，尚无研究报道冠心病（CAD）患者的血液内唾液酸蛋白水平。
我们调查了376例因疑似CAD接受选择性冠状动脉造影的患者血浆内唾液酸蛋白水平与CAD的存在或严重程度之间的关联。CAD的严重程度用狭窄冠状动脉血管和节段的数量表示。
在376例研究患者中，210例发现患有CAD（单支血管病变（1-VD），n990例；双支血管病变（2-VD），n = 65；三支血管病变（3-VD），n = 55）。与166例无CAD的患者相比，210例CAD患者的C反应蛋白（CRP）水平更高（中位数0.57对0.43 mg/L，P = 0.007）。然而，有CAD和无CAD患者的内唾液酸蛋白水平无显著差异（0.91对0.92 ng/mL，P = 0.693）。发现CRP水平根据狭窄血管数量>50%呈逐步升高：CAD（-）组为0.43，1-VD组为0.52，2-VD组为0.57，3-VD组为0.58 mg/L（P = 0.019）。CAD（-）、1-VD、2-VD和3-VD四组的内唾液酸蛋白水平无明显差异（分别为0.92、0.89、0.98和0.87 ng/mL，P = 0.785）。此外，内唾液酸蛋白水平与狭窄节段数量>50%和>25%或CRP水平之间无显著相关性。在多变量分析中，内唾液酸蛋白水平不是独立于动脉粥样硬化危险因素与CAD相关的显著因素。
发现CAD患者的血浆内唾液酸蛋白水平不高于无CAD患者，且与CAD的存在或严重程度无显著关联。
