Suzuki Rumiko, Saitou Naruya, Matsuari Osamu, Shiota Seiji, Matsumoto Takashi, Akada Junko, Kinjo Nagisa, Kinjo Fukunori, Teruya Kuniko, Shimoji Makiko, Shiroma Akino, Kato Mototsugu, Satou Kazuhito, Hirano Takashi, Asaka Masahiro, Kryukov Kirill, Moodley Yoshan, Yamaoka Yoshio
Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu City, Oita Prefecture 879-5593, Japan.
Population Genetics Laboratory, National Institute of Genetics, 1111 Yata, Mishima 411-8540, Japan.
iScience. 2022 May 30;25(7):104477. doi: 10.1016/j.isci.2022.104477. eCollection 2022 Jul 15.
A virulence bacterium, , evolved parallel to its host human, therefore, can work as a marker for tracing the human migration. We found . strains indigenous in the southernmost islands of Japanese Archipelago, Okinawa, and defined them as hspOkinawa and hpRyukyu. Genome data of the strains revealed that hspOkinawa diverged from other East Asian strains about 20,000 years ago, and that hpRyukyu diverged about 45,000 years ago. The closest strains of hpRyukyu were found from Afghanistan, Punjab, and Nepal, which suggest this strain originated in the central Asia and traveled across the Eurasian continent during Paleolithic era. The divergence date of hpRyukyu corresponds with human fossil records in Okinawa. Although it is controversial from human DNA analyses whether descendants of the Paleolithic migrants remain in the modern Japanese population, this study reveals that the bacterium of Paleolithic origin remains in the stomachs of current Japanese.
一种毒力细菌与它的宿主人类平行进化，因此可以作为追踪人类迁徙的一个标记。我们发现了……菌株原产于日本列岛最南端的岛屿冲绳，并将它们定义为hsp冲绳和hp琉球。这些菌株的基因组数据显示，hsp冲绳大约在2万年前与其他东亚菌株分化，而hp琉球大约在4.5万年前分化。hp琉球最接近的菌株发现于阿富汗、旁遮普邦和尼泊尔，这表明该菌株起源于中亚，并在旧石器时代穿越了欧亚大陆。hp琉球的分化日期与冲绳的人类化石记录相符。尽管从人类DNA分析来看，旧石器时代移民的后代是否仍存在于现代日本人群中存在争议，但这项研究表明，起源于旧石器时代的这种细菌仍存在于现代日本人的胃中。
