Suzuki Rumiko, Yamaoka Yoshio
Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine.
Nihon Rinsho. 2013 Aug;71(8):1368-73.
Helicobacter pylori is not only a well known gastroduodenal pathogen but also a useful marker for tracing prehistoric footprints of human populations. Because H. pylori transmits mainly through vertical infection and has been carried in our stomach from generation to generation, its geneology well reflects that of human. We investigated genes of H. pylori from a wide variety of ethnicity and predicted the journey of ancient people after the departure from the African Continent in 100 to 50 thousand years ago. Analysis of genotypes of single genes, multi locus sequence typing, and also with the aid of next generation sequencer, we identified a group of H. pylori strains that diverged remarkably old era in Okinawa, Japan.
幽门螺杆菌不仅是一种广为人知的胃十二指肠病原体，也是追踪人类史前足迹的有用标志物。由于幽门螺杆菌主要通过垂直感染传播，并且代代相传地存在于我们的胃中，其谱系很好地反映了人类的谱系。我们研究了来自各种不同种族的幽门螺杆菌基因，并预测了大约在10万至5万年前离开非洲大陆后古代人类的迁徙历程。通过对单个基因的基因型分析、多位点序列分型，以及借助新一代测序仪，我们在日本冲绳发现了一组分化时间极为久远的幽门螺杆菌菌株。
