Stosik Michał, Tokarz-Deptuła Beata, Deptuła Wiesław
Institute of Biological Science, Faculty of Biological Sciences, University of Zielona Góra, Zielona Góra, Poland.
Institute of Biology, University of Szczecin, Szczecin, Poland.
Front Immunol. 2022 Jun 2;13:902941. doi: 10.3389/fimmu.2022.902941. eCollection 2022.
Haematopoiesis in fish and mammals is a complex process, and many aspects regarding its model and the differentiation of haematopoietic stem cells (HSCs) still remain enigmatic despite advanced studies. The effects of microenvironmental factors or HSCs niche and signalling pathways on haematopoiesis are also unclear. This review presents as a model organism for studies on haematopoiesis in vertebrates and discusses the development of this process during the embryonic period and in adult fish. It describes the role of the microenvironment of the haematopoietic process in regulating the formation and function of HSCs/HSPCs (hematopoietic stem/progenitor cells) and highlights facts and research areas important for haematopoiesis in fish and mammals.
鱼类和哺乳动物的造血作用是一个复杂的过程，尽管已有深入研究，但关于其模型以及造血干细胞（HSCs）分化的许多方面仍不明确。微环境因素或造血干细胞龛及信号通路对造血作用的影响也尚不清楚。本文将[具体鱼类名称]作为脊椎动物造血研究的模式生物进行介绍，并讨论该过程在胚胎期和成鱼中的发育情况。它描述了造血过程的微环境在调节造血干细胞/造血祖细胞（HSPCs）形成和功能中的作用，并强调了对鱼类和哺乳动物造血作用重要的事实和研究领域。
